HFOV叠加CMV联合西地那非、注射用牛肺表面活性剂治疗重度PPHN的效果

doi:10.3969/j.issn.1007-3205.2020.03.016

河北医科大学学报

HFOV叠加CMV联合西地那非、注射用牛肺表面活性剂治疗重度PPHN的效果

1.河北省廊坊市人民医院儿科，河北廊坊 065000；2.河北省廊坊市人民医院超声科，河北廊坊 065000

出版日期:2020-03-25 发布日期:2020-04-02
作者简介:杨海娟（1980-），女，河北廊坊人，河北省廊坊市人民医院副主任医师，医学学士，从事儿科疾病诊治研究。
基金资助:
廊坊市科学技术研究与发展计划（2016013180）

Effect of HFOV plus CMV combined with Sildenafil and calf pulmonary surfactant for injection on severe PPHN#br#

1.Department of Pediatric, Langfang People′s Hospital,Hebei Province, Langfang 065000，China;
2.Department of Ultrasound， Langfang People′s Hospital, Hebei Province, Langfang 065000， China

Online:2020-03-25 Published:2020-04-02

摘要/Abstract

摘要： ［摘要］
目的探讨高频振荡通气（high frequency oscillatory ventilation,HFOV）叠加常频通气（constant frequency ventilation, CMV）联合西地那非、注射用牛肺表面活性剂治疗重度新生儿持续性肺动脉高压（persistent pulmonaryhypertension of newborn,PPHN）的临床效果。
方法选取重度PPHN患儿86例，按照随机数字表法分为研究组和对照组各43例，对照组给予西地那非、CMV治疗，研究组给予HFOV叠加CMV联合西地那非，注射用牛肺表面活性剂治疗。比较2组患儿治疗前及治疗后6，12，24，36 h的氧合指数（oxygenation index,OI）、血氧饱和度（oxygen saturation of blood,SpO2），治疗相关指标及治疗疗效。
结果研究组治疗后各时点的OI明显低于对照组，研究组治疗后12，24，36 h的SpO2明显高于对照组，差异有统计学意义（P＜0.01）。各组治疗后不同时点的OI与治疗前比较明显降低，研究组治疗后各时点的SpO2与治疗前比较明显升高，对照组治疗后36 h的SpO2与治疗前比较明显升高，差异有统计学意义（P＜0.01）。研究组的吸氧时间、呼吸机使用时间、住院时间、住院费用明显少于对照组，差异有统计学意义（P＜0.01）。研究组治疗总有效率明显高于对照组，差异有统计学意义（P＜0.05）。
结论 HFOV叠加CMV联合西地那非，注射用牛肺表面活性剂治疗重度PPHN患儿，可有效改善肺氧合功能，减少呼吸机使用时间、氧疗时间，提高治疗疗效。

关键词: 高血压, 肺性, 胸壁震荡通气, 西地那非

Abstract: ［Abstract］ ObjectiveTo investigate the clinical effects of high frequency oscillatory ventilation(HFOV) combined with normal frequency ventilation(CMV) combined with Sildenafil and colisulla on severe neonatal persistent pulmonary hypertension(PPHN).
〖WTHZ〗MethodsA total of 86 children with severe PPHN were selected and divided into a study group and a control group with 43 cases each according to the random number table method. The control group was treated with sildenafil and CMV treatment. The oxygenation index(OI), oxygen saturation of blood(SpO2), treatment-related indexes, and treatment efficacy were compared between patients of two groups before and 6 h, 12 h, 24 h, 36 h after treatment.
〖WTHZ〗ResultsThe OI of the study group was significantly lower than that of the control group at each time point after treatment. The SpO2 at 12 h, 24 h and 36 h after treatment was significantly higher in the study group than in the control group(P＜0.01). The OI at different time points after treatment was significantly lower than that before treatment. The SpO2 at each time point after treatment was significantly higher than that before treatment. The SpO2 at 36 h after treatment was significantly higher than that before treatment with statistical significance(P＜0.01). The oxygen inhalation time, ventilator use time, hospitalization time, and hospitalization cost of the study group were significantly lower than those of the control group, and the difference was statistically significant(P＜0.01). The total effective rate of the study group was significantly higher than that of the control group, the difference was statistically significant(P＜0.05).
〖WTHZ〗ConclusionSildenafil combined with calsurf and HFOV superimposed CMV in children with heavy negative PPHN can effectively improve pulmonary oxygenation, reduce ventilator use time, oxygen therapy time and improve treatment efficacy.

Key words: hypertension, pulmonary, chest wall oscillation, sildenafil

杨海娟1，许泽辉1，张梦华2. HFOV叠加CMV联合西地那非、注射用牛肺表面活性剂治疗重度PPHN的效果[J]. 河北医科大学学报, doi: 10.3969/j.issn.1007-3205.2020.03.016.

YANG Hai-juan1, XU Ze-hui1, ZHANG Meng-hua2. Effect of HFOV plus CMV combined with Sildenafil and calf pulmonary surfactant for injection on severe PPHN#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.1007-3205.2020.03.016.

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HFOV叠加CMV联合西地那非、注射用牛肺表面活性剂治疗重度PPHN的效果

Effect of HFOV plus CMV combined with Sildenafil and calf pulmonary surfactant for injection on severe PPHN#br#

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