关键词: 乙型肝炎病毒, 血清流行病学研究, 育龄期妇女

Abstract: Objective〖HTSS〗To determine seroepidemiological characteristics of hepatitis B virus （HBV） among rural women of child-bearing age in Dali prefecture and to provide the scientific basis for prevention and control of HBV.
〖WTHZ〗Methods〖HTSS〗A total of 2 063 rural women of child-bearing age from 15 to 49 years old were selected by stratified cluster sampling and random number table. The subjects were investigated by questionnaire survey and samples of blood were collected， and HBV serological markers were tasted by enzyme linked immunosorbent assay.
〖WTHZ〗Results〖HTSS〗Among 2 063 rural women of childbearing age, 45 cases(2.18%) were positive for HBsAg, 734 cases(35.58%) for HBsAb and 243 cases(11.78%) for HBcAb. There were 7 detection patterns of HBV serological markers, mainly susceptible(59.38%). The positive rate of HBcAb in the childbearing age women in mountainous areas was higher than that in non mountainous areas, and the positive rate of HBcAb in the childbearing age women in ethnic minorities was higher than that in the Han nationality, the difference was statistically significant(P＜0.05). With the increase of age, the positive rate of HBsAg and HBcAb in women of childbearing age was higher, the difference was statistically significant(P＜0.05), but there was no significant difference in the positive rate of HBsAb in women of childbearing age(P＞0.05). The positive rates of HBsAg and HBcAb in women of childbearing age with a history of hepatitis B vaccine immunization were lower than those without a history of hepatitis B vaccine immunization, and the positive rates of HBsAb were higher than those without a history of hepatitis B vaccine immunization(P＜0.05).
〖WTHZ〗Conclusion〖HTSS〗The positive rate of HBsAg among rural women of child-bearing age in Dali prefecture is close to the low level， however，about 60% of the population are still susceptible for HBV. We should strengthen the propaganda of hepatitis B knowledge and promote hepatitis B vaccination among rural women in child-bearing age before pregnancy.

Key words: hepatitis B virus, seroepidemiologic studies, women of child-bearing age