河北医科大学学报

• 论著 • 上一篇    下一篇

早产儿脑白质损伤发病影响因素及不同损伤程度特征分析

  

  1. 1.河北省秦皇岛市妇幼保健院放射科，河北 秦皇岛 066000；2.河北省秦皇岛市第三人民医院核磁室，
    河北 秦皇岛 066000；3.河北省秦皇岛市第三人民医院肺病科，河北 秦皇岛 066000
  • 出版日期:2020-07-25 发布日期:2020-07-28
  • 作者简介:张洪涛（1982-），男，河北秦皇岛人，河北省秦皇岛市妇幼保健院主治医师，医学硕士，从事放射学诊断研究。
  • 基金资助:
    秦皇岛市科技计划（201602A054）

Analysis of the influencing factors and characteristics of different degrees of brain white matter injury in premature infants

  1. 1.Depatment of Radiology, Maternal and Child Health Hospital of Qinhuangdao,Hebei Province，
    Qinhuangdao 066000, China; 2.Depatment of MRI, the Third People′s Hospital of Qinhuangdao,
    Hebei Province， Qinhuangdao 066000, China; 3.Depatment of Pulmonary Disease, the Third
    People′s Hospital of Qinhuangdao, Hebei Province， Qinhuangdao 066000, China
  • Online:2020-07-25 Published:2020-07-28

HTML

PDF (PC)

162

摘要： 目的 分析早产儿脑白质损伤发病影响因素及不同损伤程度特征。
方法 选择脑白质损伤早产儿126例作为观察组，另选择足月生产正常儿88例作为对照组，比较2组性别、胎龄、分娩方式、围生期并发症、相关血常规及血气指标、是否行机械通气、妊娠结局等。采用Logistic多因素回归分析确定早产儿脑白质损伤的危险因素。进一步分析观察组不同程度脑白质损伤患儿的临床资料，探讨不同程度脑白质损伤早产儿的临床特征。
结果 观察组胎龄，剖宫产占比，肌酸激酶、C反应蛋白（C-reactive protein,CRP）、白蛋白水平，出生后感染和宫内窘迫发生率高于对照组，差异有统计学意义（P＜0.05或P＜0.01）。Logistic多因素回归分析显示，低胎龄、CRP升高、出生后感染、宫内窘迫是早产儿脑白质损伤发生的独立危险因素。随着病情程度的加重，患儿出生后感染、CRP升高、宫内窘迫发生率逐渐升高（P＜0.05或P＜0.01）。
结论 出生后感染、低胎龄、CRP升高及宫内窘迫是影响早产儿发生脑白质损伤的危险因素，随着病情程度加重，患儿出生后感染、CRP升高、宫内窘迫发生率逐渐升高。做好围生期健康保健工作可降低早产儿脑白质损伤发生率。

关键词: 脑白质损伤, 婴儿, 早产, 影响因素分析

Abstract: Objective〖HTSS〗To analyze the influencing factors and the characteristics of different degrees of brain white matter injury in preterm infants.
〖WTHZ〗Methods〖HTSS〗126 cases of premature infants with brain white matter injury were selected as the observation group, and 88 cases of full-term normal infants were selected as the control group. Logistic regression analysis was used to determine the risk factors of brain white matter injury in preterm infants. Further analyze the clinical data of different degrees of brain white matter injury in the observation group, and explore the clinical characteristics of premature infants with different degrees of brain white matter injury.
〖WTHZ〗Results〖HTSS〗In the observation group, the fetal age, the proportion of cesarean section, the level of myocardial enzyme, C-reactive protein(CRP), albumin, the incidence of post natal infection and intrauterine distress were significantly higher than those in the control group(P＜0.05 or P＜0.01). Logistic regression analysis showed that low gestational age, high CRP, infection after birth, and intrauterine distress were independent risk factors for the occurrence of brain white matter injury in preterm infants. The incidence of infection, CRP and intrauterine distress increased with the severity of the disease(P＜0.05 or P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗Postnatal infection, low gestational age, high CRP and intrauterine distress are the risk factors for the occurrence of brain white matter injury in preterm infants. With the aggravation of the disease, the incidence of postnatal infection, high CRP and intrauterine distress gradually increases. The incidence of brain white matter injury in preterm infants can be reduced by doing a good job of perinatal health care.

Key words: brain white matter injury, infant, premature； root cause analysis

版权所有 © 《河北医科大学学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发