河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (11): 1291-1296,1317.doi: 10.3969/j.issn.1007-3205.2022.11.011

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高强度超声波联合加巴喷丁对神经病理性疼痛患者miR-19a、miR-30b、miR-29c的影响

  

  1. 1.河北大学附属医院疼痛科，河北 保定 071000;2.河北大学附属医院神经内科,河北 保定  071000

  • 出版日期:2022-11-25 发布日期:2022-12-28
  • 作者简介:吉伟丽（1982-），女，河北深泽人，河北大学附属医院主管护师，医学学士，从事疼痛科疾病护理研究。
  • 基金资助:
    河北省医学科学研究课题计划（20200574）

Effect of high-intensity ultrasound combined with gabapentin on miR-19a, miR-30b and miR-29c in patients with neuropathic pain

  1. 1.Department of Pain Management, the Affiliated Hospital of Hebei University, Baoding 071000， China; 
    2.Department of Neurology， the Affiliated Hospital of Hebei University, Baoding 071000， China

  • Online:2022-11-25 Published:2022-12-28

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摘要： 目的 探究高强度超声波联合加巴喷丁对神经病理性疼痛患者微小RNA-19a（microrna-19a，miR-19a）、微小RNA-30b(microrna-30b，miR-30b）、微小RNA-29c(microrna-29c，miR-29c）的影响。
方法 选取神经病理性疼痛患者72例，按照随机法将其分为对照组35例和联合组37例。对照组使用加巴喷丁治疗，联合组在对照组基础上联合高强度超声波治疗。比较2组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale, NIHSS）评分、改良Barthel指数、白细胞介素6（interleukin-6，IL-6）、C反应蛋白（C-reactive protein，CRP）、视觉模拟评分法（visual analogue scale，VAS）评分、神经病理性疼痛量表（neuropathic pain scale，NPS）评分、CD4+、CD8+、CD4+/CD8+、miR-19a、miR-30b、miR-29c水平、治疗效果和不良反应发生情况。
结果 治疗后，2组NIHSS评分、IL-6、CRP、VAS评分、NPS评分、miR-19a、miR-30b、miR-29c表达水平低于治疗前，改良Barthel指数、CD4+、CD8+、CD4+/CD8+水平高于治疗前，联合组NIHSS评分、IL-6、CRP、VAS评分、NPS评分、miR-19a、miR-30b、miR-29c表达水平低于对照组，改良Barthel指数、CD4+、CD8+、CD4+/CD8+水平高于对照组（P＜0.05）。联合组临床治疗总有效率高于对照组（P＜0.05）。2组不良反应发生率差异无统计学意义（P＞0.05）。
结论 高强度超声波联合加巴喷丁治疗神经病理性疼痛患者，能明显改善神经功能和免疫功能，减轻疼痛感和炎症反应，调控miR-19a、miR-30b、miR-29c表达，治疗效果明显。


关键词: 神经痛, 加巴喷丁, 高强度超声波

Abstract: Objective To investigate the effect of high-intensity ultrasound combined with gabapentin on microRNA-19a(miR-19a), microRNA-30b(miR-30b), microRNA-29c(miR-29c) in patients with neuropathic pain. 
Methods A total of 72 patients with neuropathic pain were selected and randomly divided into a control group(n=35) and a combination group(n=37). The control group was treated with gabapentin, and the combination group was treated with high-intensity ultrasound on the basis of the control group. The scores of the National Institute of Health Stroke Scale(NIHSS), modified Barthel index, and the levels of interleukin-6(IL-6), C-reactive protein(CRP), visual analogue scale(VAS) score, neuropathic pain scale(NPS) score, the levels of CD4+, CD8+, CD4+/CD8+, miR-19a, miR-30b and miR-29c, therapeutic effect and occurrence of adverse reactions were compared between two groups. 
Results After treatment, the NIHSS score, IL-6, CRP, VAS score, NPS score, miR-19a, miR-30b and miR-29c expression levels in the two groups were lower than those before treatment, and the levels of improved Barthel index, CD4+, CD8+, CD4+/CD8+ were higher than those before treatment. After treatment, NIHSS score, IL-6, CRP, VAS score, NPS score, miR-19a, miR-30b, and miR-29c expression levels in the combination group were lower than those in the control group, while the levels of modified Barthel index, CD4+, CD8+ and CD4+/CD8+ were higher than those of the control group(P＜0.05). The total effective rate of clinical treatment in the combination group was higher than that in the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05). 
Conclusion High-intensity ultrasound combined with gabapentin in the treatment of patients with neuropathic pain can significantly improve neurological function and immune function, reduce pain and inflammatory response, and regulate the expression of miR-19a, miR-30b and miR-29c, showing a significant therapeutic effect.


Key words: neuralgia, gabapentin, high-intensity ultrasound

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