心血管疾病中IVUS-VH斑块特征与CTRP9、SAA及Hcy的关系

doi:10.3969/j.issn.1007-3205.2023.02.014

摘要/Abstract

摘要： 目的探讨冠心病患者血管内超声虚拟组织学（intravascular ultrasound virtual histology，IVUS-VH）斑块特征与血清脂肪细胞因子C1q/肿瘤坏死因子相关蛋白9（adipocytokine C1q / tumor necrosis factor associated protein 9，CTRP9）、淀粉样蛋白A（serum amyloid A，SAA）和同型半胱氨酸（homocysteine，Hcy）的关系。
方法选取在我院治疗的冠心病患者120例，其中急性冠状动脉综合征（acute coronary syndrome，ACS）患者65例（ACS组），稳定型心绞痛（stable angina pectoris，SAP）患者55例（SAP组），同时选取志愿者50例作为对照组，检测各组血清CTRP9、SAA及Hcy水平，同时给予ACS和SAP组患者IVUS-VH检查。
结果 ACS组患者血清CTRP9为（3.02±0.45）×10-2mg/L，明显低于SAP组（P＜0.05），而SAA和Hcy分别为（4.45±1.01）mg/L和（24.42±3.36）μmol/L，明显高于SAP组（P＜0.05）。对照组血清CTRP9、SAA及Hcy明显低于ACS组和SAP组（P＜0.05）。ACS组IVUS-VH参数坏死组织面积及薄纤维帽斑块（thin cap of fibrous plaque，TCFA）发生率分别为（32.20±7.78）%和49.23%，明显高于SAP组，差异有统计学意义（P＜0.05），而纤维组织面积为（44.65±11.02）%，明显低于SAP组（P＜0.05）。坏死组织面积与CTRP9呈负相关（P＜0.05），而与SAA和Hcy呈正相关（P＜0.05）；纤维组织面积与SAA呈负相关（P＜0.05）。TCFA患者血清CTRP9为（2.89±0.58）×10-2mg/L，明显低于非TCFA组（P＜0.05），而SAA和Hcy分别为（4.89±1.12）mg/L和（26.62±3.12）μmol/L，明显高于非TCFA组（P＜0.05）。CRTP9、SAA及Hcy预测TCFA的ROC曲线下面积分别为0.712、0.815和0.844（P＜0.05）。
结论 ACS和SAP患者血清CTRP9、SAA和Hcy有明显差异，与IVUS-VH参数有一定相关性，值得进一步研究。

关键词: 冠心病, 血清淀粉样蛋白A, 同型半胱氨酸

Abstract: Objective To investigate the relationship between plaque characteristics of intravascular ultrasound virtual histology (IVUS-VH) and serum adipocytokine C1q/tumor necrosis factor associated protein 9 (CTRP9), serum amyloid A (SAA) and homocysteine (Hcy) in patients with coronary heart disease (CHD).
Methods A total of 120 patients with CHD treated in our hospital were selected, including 65 patients with acute coronary syndrome (ACS group) and 55 patients with stable angina pectoris (SAP group). Another 50 volunteers were selected as control group, the levels of serum CTRP9, SAA and Hcy in ACS and SAP group were detected, and IVUS-VH was performed in the meantime in both ACS group and SAP group.
Results The serum CTRP9 in the ACS group was (3.02±0.45)×10-2mg/L, which was significantly lower than that in the SAP group, with statistical significance (P＜0.05), while the levels of SAA and Hcy were (4.45±1.01) mg/L and (24.42±3.36) μmol/L, which were significantly higher than those in the SAP group (P＜0.05). The serum levels of CTRP9, SAA and Hcy in the control group were significantly lower than those in the ACS group and the SAP group (P＜0.05). The IVUS-VH parameter necrotic tissue area and the incidence of thin cap of fibroatheroma (TCFA) in the ACS group were (32.20±7.78)% and 49.23%, respectively, which were significantly higher than those in the SAP group, with statistical significance (P＜0.05). The tissue area was (44.65±11.02)%, which was significantly lower than that of the SAP group (P＜0.05). Necrotic tissue area was negatively correlated with CTRP9 (P＜0.05), but positively correlated with SAA and Hcy (P＜0.05); fibrous tissue area was negatively correlated with SAA (P＜0.05). The serum CTRP9 of TCFA patients was (2.89±0.58)×10-2mg/L, which was significantly lower than that of the non-TCFA group (P＜0.05), while the levels of SAA and Hcy were (4.89±1.12) mg/L and (26.62±3.12) μmol/L, respectively significantly higher than those in the non-TCFA group (P＜0.05).The areas under ROC curve of CTRP9, SAA and Hcy in predicting TCFA were 0.712, 0.815 and 0.844, respectively (P＜0.05).
Conclusion There are significant differences in serum CTRP9, SAA and Hcy between ACS patients and SAP patients, which are correlated with IVUS-VH parameters, and worthy of further study.

Key words: coronary disease, serum amyloid A protein, homocysteine

胡植双, 王健美, 赵岩亮. 心血管疾病中IVUS-VH斑块特征与CTRP9、SAA及Hcy的关系 [J]. 河北医科大学学报, 2023, 44(2): 194-198.

HU Zhi-shuang, WANG Jian-mei, ZHAO Yan-liang. Relationship between IVUS-VH plaque characteristics and CTRP9, SAA and Hcy in cardiovascular diseases[J]. Journal of Hebei Medical University, 2023, 44(2): 194-198.

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心血管疾病中IVUS-VH斑块特征与CTRP9、SAA及Hcy的关系

Relationship between IVUS-VH plaque characteristics and CTRP9, SAA and Hcy in cardiovascular diseases

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