两种药物联合治疗对病毒性脑炎相关癫痫患儿脑电图和血清IL-6、TNF-α水平的影响

doi:10.3969/j.issn.1007-3205.2023.03.014

河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (3): 315-318.doi: 10.3969/j.issn.1007-3205.2023.03.014

两种药物联合治疗对病毒性脑炎相关癫痫患儿脑电图和血清IL-6、TNF-α水平的影响

1.海军军医大学第一附属医院药剂科，上海 200433；2.海军军医大学第一附属医院脑外科，上海 200433

出版日期:2023-03-25 发布日期:2023-03-24
作者简介:俞登荣(1985-)，男，安徽滁州人，海军军医大学第一附属医院药师，药学学士，从事疾病的药物疗法研究。
基金资助:
上海市卫生局重点资助项目（20204029）

Effects of combined treatment of two drugs on EEG and serum IL-6 and TNF-α level in children with viral encephalitis-related seizures

1.Department of Pharmacy, the First Affiliated Hospital of Naval Military Medical University,
Shanghai 200433, China; 2.Department of Brain Surgery, the First Affiliated Hospital of
Naval Military Medical University, Shanghai 200433, China

Online:2023-03-25 Published:2023-03-24

摘要/Abstract

摘要： 目的分析探讨左乙拉西坦与奥卡西平对病毒性脑炎相关癫痫患儿脑电背景活动和血清白细胞介素6(interleukin-6，IL-6)、肿瘤坏死因子α(tumor necrosis factor-α，TNF-α)水平的影响。
方法选取病毒性脑炎后癫痫患儿118例，按照随机数字表法将所有患者简单随机分为对照组和研究组2组，其中研究组给予奥卡西平进行治疗，对照组给予左乙拉西坦进行治疗，2组均持续治疗6个月。分别记录2组在治疗1个月和3个月以及6个月后的癫痫控制率，分别在治疗前、治疗3个月后和治疗6个月后采用长程视频脑电图对脑电放电功能进行评估分析，同时记录2组的TNF-α和IL-6水平变化情况。
结果研究组在治疗1个月、治疗3个月以及治疗半年后的完全控制率以及总有效率均显著高于对照组（P＜0.05）。治疗后，2组α和θ功率均显著高于组治疗前（P＜0.05）；研究组治疗3个月后及6个月后的α和θ功率均显著高于对照组（P＜0.05）。2组的TNF-α和IL-6水平均低于治疗前，研究组低于对照组（P＜0.05）。
结论对于病毒性脑炎相关癫痫患儿采用奥卡西平进行治疗能够有效降低其血清炎性因子的水平，同时对其脑电背景活动的影响也相对左乙拉西坦较小，安全性高，值得在临床上加以推广运用。

关键词: 脑炎,病毒性, 癫痫, 左乙拉西坦, 奥卡西平

Abstract: Objective To investigate the effects of levetiracetam and oxazepine on EEG background activity, serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in children with viral meningitis-related seizures.
Methods A total of 118 patients with seizure due to viral encephalitis were selected and divided into the control group and the research group according to random number table method. The research group was given oxazepine, and the control group was given levetiracetam. Both groups were treated for 6 consecutive months. The seizure control rate of the two groups at 1 month, 3 months and 6 months after treatment were recorded, and the EEG discharge function before treatment, at 3 months and 6 months after treatment were evaluated and analyzes. The changes in TNF-α and IL-6 levels were recorded.
Results The complete control rate and total effective rate in the research group were significantly higher than those in the control group at 1 month, 3 months and 6 months after treatment (P＜0.05). After treatment, α and θ power in both groups was significantly higher than that before treatment (P＜0.05). At 3 months and 6 months after treatment,α and θ power in the research group was significantly higher than that of the control group (P＜0.05). The levels of TNF-α and IL-6 in both groups were lower than those before treatment, and lower in the research group than in the control group (P＜0.05).
Conclusion Oxazepine can effectively reduce the level of serum inflammatory factors in children with viral meningitis-related seizures, and its effect on the background activity of EEG is smaller than that of levetiracetam, with good safety . Therefore, it is worthy of popularization and clinical application.

Key words: encephalitis, viral, epilepsy, levoethoxetam, ocazepine

俞登荣, 陈剑春, 吕焕焕, 姬瑞瑞. 两种药物联合治疗对病毒性脑炎相关癫痫患儿脑电图和血清IL-6、TNF-α水平的影响 [J]. 河北医科大学学报, 2023, 44(3): 315-318.

YU Deng-rong, CHEN Jian-chun, LYU Huan-huan, JI Rui-rui. Effects of combined treatment of two drugs on EEG and serum IL-6 and TNF-α level in children with viral encephalitis-related seizures[J]. Journal of Hebei Medical University, 2023, 44(3): 315-318.

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两种药物联合治疗对病毒性脑炎相关癫痫患儿脑电图和血清IL-6、TNF-α水平的影响

Effects of combined treatment of two drugs on EEG and serum IL-6 and TNF-α level in children with viral encephalitis-related seizures

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