苯磺酸瑞马唑仑复合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果研究

doi:10.3969/j.issn.1007-3205.2023.03.019

河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (3): 338-341,352.doi: 10.3969/j.issn.1007-3205.2023.03.019

苯磺酸瑞马唑仑复合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果研究

重庆市大足区人民医院麻醉科，重庆 402360

出版日期:2023-03-25 发布日期:2023-03-24
作者简介:任青竹（1982-），女，重庆人，重庆市大足区人民医院副主任医师，医学学士，从事临床麻醉学的研究。
基金资助:
重庆市大足区科技发展项目（DZKJ,2020ACC1009）；重庆市卫生计生委中医药科技计划项目（ZY201703062）

Application effect of remazolam besylate combined with alfentanil in painless gastrointestinal endoscopy in elderly patients

Department of Anesthesiology, People′s Hospital of Dazu District, Chongqing City, Chongqing 402360, China

Online:2023-03-25 Published:2023-03-24

摘要/Abstract

摘要： 目的探讨苯磺酸瑞马唑仑复合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果。
方法选取医院收治的208例拟行无痛胃肠镜检查的老年患者，依照随机数字表法分为研究组和对照组，每组104例。对照组采用丙泊酚复合阿芬太尼麻醉，研究组采用苯磺酸瑞马唑仑复合阿芬太尼麻醉。比较2组患者苏醒时间、检查时间、离室时间，不同时点间［给药前（T1），给药后5 min（T2），给药后10 min（T3），给药后15 min（T4）］血压、心率、血氧饱和度，镇静效果以及不良反应发生情况。
结果研究组患者苏醒时间、离室时间均短于对照组（P＜0.05）；2组患者T2时刻收缩压、舒张压、心率、血氧饱和度均低于T1时刻（P＜0.05），研究组T2时刻收缩压、舒张压、心率、血氧饱和度均高于对照组（P＜0.05），对照组患者T3、T4时刻收缩压、舒张压、心率、血氧饱和度均高于T2时刻（P＜0.05）；研究组镇静效果优良率高于对照组（P＜0.05）；研究组总不良反应发生率低于对照组（P＜0.05）。
结论苯磺酸瑞马唑仑复合阿芬太尼用于老年患者无痛胃肠镜检查可以缩短苏醒时间，对血液动力学影响较小，患者不良反应发生率低，安全可靠。

关键词: 胃镜检查, 结肠镜检查, 阿芬太尼

Abstract: Objective To investigate the application effect of remazolam besylate combined with alfentanil in painless gastrointestinal endoscopy in elderly patients.
Methods A total of 208 elderly patients who were admitted to the hospital and planned to undergo painless gastrointestinal endoscopy were selected and divided into the research group (n=104) and the control group (n=104) according to the random number table method. The control group was anesthetized with propofol combined with alfentanil, and the research group was anesthetized with remazolam besylate combined with alfentanil. The recovery time, examination time, and time of leaving the room, and the blood pressure, heart rate, oxygen saturation at different time points ［before administration (T1), at 5 min after administration (T2), at 10 min after administration (T3), and at 15 min after administration (T4)］, sedative effects, and adverse reactions of the two groups were compared.
Results The recovery time and the time of leaving the room in the research group were shorter than those in the control group (P＜0.05). The systolic pressure, diastolic pressure, heart rate, and blood oxygen saturation at T2 in both groups were lower than those at T1 (P＜0.05), and the systolic pressure, diastolic pressure, heart rate, and blood oxygen saturation at T2 in the research group were higher than those in the control group (P＜0.05) . The systolic pressure, diastolic pressure, heart rate and blood oxygen saturation at T3 and T4 in the control group were higher than those at T2 (P＜0.05). The excellent and good rate of sedative effect in the research group was higher than that in the control group (P＜0.05). The total incidence of adverse reactions in the research group was lower than that in the control group (P＜0.05).
Conclusion Remazolam besylate combined with alfentanil for painless gastrointestinal endoscopy in elderly patients can shorten the recovery time, have less impact on hemodynamics, and have a low incidence of adverse reactions in patients, which is safe and reliable.

Key words: gastroscopy, colonoscopy, alfentanil

任青竹, 杨寿娟, 阮定红, 周丹, 刘霜. 苯磺酸瑞马唑仑复合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果研究 [J]. 河北医科大学学报, 2023, 44(3): 338-341,352.

REN Qing-zhu, YANG Shou-juan, RUAN Ding-hong, ZHOU Dan, LIU Shuang. Application effect of remazolam besylate combined with alfentanil in painless gastrointestinal endoscopy in elderly patients [J]. Journal of Hebei Medical University, 2023, 44(3): 338-341,352.

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苯磺酸瑞马唑仑复合阿芬太尼在老年患者无痛胃肠镜检查中的应用效果研究

Application effect of remazolam besylate combined with alfentanil in painless gastrointestinal endoscopy in elderly patients

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