血清SERPINA1、CTGF、T-AOC在子宫肌瘤患者中的表达水平及临床意义

doi:10.3969/j.issn.1007-3205.2023.04.013

河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (4): 434-438.doi: 10.3969/j.issn.1007-3205.2023.04.013

血清SERPINA1、CTGF、T-AOC在子宫肌瘤患者中的表达水平及临床意义

1.河北省廊坊市中医医院检验科，河北廊坊 065000；2.河北省廊坊市人民医院产科，河北廊坊 065000；3.河北省廊坊市中医医院妇产科，河北廊坊 065000

出版日期:2023-04-20 发布日期:2023-04-20
作者简介:白金录（1986-），男，黑龙江黑河人，河北省廊坊市中医医院主管检验师，医学学士，从事临床检验研究。
基金资助:
廊坊市科学技术研究与发展计划(2019013120)

Expression level and clinical significance of serum SERPINA1, CTGF and T-AOC in patients with uterine leiomyoma

1.Department of Clinical Laboratory， Langfang Hospital of Traditional Chinese Medicine, Hebei Province,
Langfang 065000, China; 2.Department of Obstetrics, Langfang People′s Hospital, Hebei Province,
Langfang 065000, China; 3.Department of Obstetrics and Gynecology, Langfang Hospital of
Traditional Chinese Medicine, Hebei Province, Langfang 065000, China

Online:2023-04-20 Published:2023-04-20

摘要/Abstract

摘要： 目的探讨血清Serpin家庭成员1(serpin family A member 1，SERPINA1)、结缔组织生长因子(connective tissue growth factor，CTGF) 、总抗氧化能力（total antioxidation capability,T-AOC）在子宫肌瘤患者中的表达情况及其临床意义。
方法选取子宫肌瘤患者82例纳入子宫肌瘤组，另选取同期健康体检者68例作为健康对照组。比较2组血清SERPINA1、CTGF、T-AOC表达情况，比较不同临床特征子宫肌瘤患者血清SERPINA1、CTGF、T-AOC表达情况，分析血清SERPINA1、CTGF、T-AOC与子宫肌瘤的相关性，分析血清SERPINA1、CTGF、T-AOC检测诊断子宫肌瘤的效能。
结果子宫肌瘤组血清SERPINA1、CTGF水平高于健康对照组，T-AOC水平低于健康对照组（P＜0.05）；有阴道不规则出血子宫肌瘤患者血清SERPINA1、CTGF水平高于无阴道不规则出血子宫肌瘤患者，T-AOC水平低于无阴道不规则出血子宫肌瘤患者（P＜0.05）。Spearman相关系数分析结果显示，血清SERPINA1、CTGF与子宫肌瘤呈明显正相关，T-AOC与子宫肌瘤呈明显负相关（P＜0.05）。血清SERPINA1、CTGF、T-AOC联合检测诊断效能明显优于单项检测(P＜0.001)。
结论血清SERPINA1、CTGF、T-AOC在子宫肌瘤患者中呈现异常表达，三项指标联合检测诊断子宫肌瘤的效能更高。

关键词: 平滑肌瘤, Serpin家庭成员1, 结缔组织生长因子, 总抗氧化能力

Abstract: Objective To investigate the expression and clinical significance of serum serpin family A member 1 (SERPINA1), connective tissue growth factor (CTGF), and total antioxidant capacity (T-AOC) in patients with uterine leiomyoma.
Methods A total of 82 patients with uterine leiomyoma were included in the uterine leiomyoma group, and 68 healthy people undergoing physical examination during the same period were selected as the healthy control group. The expression of serum SERPINA1, CTGF, T-AOC in the two groups was compared. The expression of SERPINA1, CTGF, T-AOC in the serum of patients with different clinical characteristics of uterine leiomyoma was compared. The correlation between SERPINA1, CTGF, T-AOC and uterine leiomyoma was analyzed, and the efficacy of SERPINA1, CTGF, and T-AOC in the detection of uterine leiomyoma was analyzed.
Results The levels of SERPINA1 and CTGF in serum of uterine leiomyoma group were higher than those of healthy control group, while the levels of T-AOC were lower than those of healthy control group (P＜0.05). Serum SERPINA1 and CTGF levels in patients with uterine leiomyoma and irregular vaginal bleeding were higher than those without irregular vaginal bleeding, and T-AOC levels were lower than those without irregular vaginal bleeding (P＜0.05). Spearman correlation coefficient analysis showed that serum SERPINA1 and CTGF were significantly positively correlated with uterine leiomyoma, while T-AOC was significantly negatively correlated with uterine leiomyoma (P＜0.05). The diagnostic efficacy of combined detection of serum SERPINA1, CTGF and T-AOC was significantly better than that of single detection (P＜0.001).
Conclusion Serum SERPINA1, CTGF and T-AOC are abnormally expressed in patients with uterine leiomyoma, and the combined detection of these three indicators is more effective in the diagnosis of uterine leiomyoma.

Key words: leiomyoma, serpin family member 1, connective tissue growth factor, total antioxidant capacity

白金录, 刘照龙, 杨丽娜, 卞海艳, 李侠. 血清SERPINA1、CTGF、T-AOC在子宫肌瘤患者中的表达水平及临床意义 [J]. 河北医科大学学报, 2023, 44(4): 434-438.

BAI Jin-lu, LIU Zhao-long, YANG Li-na, BIAN Hai-yan, LI Xia. Expression level and clinical significance of serum SERPINA1, CTGF and T-AOC in patients with uterine leiomyoma [J]. Journal of Hebei Medical University, 2023, 44(4): 434-438.

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血清SERPINA1、CTGF、T-AOC在子宫肌瘤患者中的表达水平及临床意义

Expression level and clinical significance of serum SERPINA1, CTGF and T-AOC in patients with uterine leiomyoma

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