乳腺癌超声征象与P120ctn、Ki67表达水平的相关性

doi:10.3969/j.issn.10073205.2017.03.017

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨连环蛋白P120ctn和核增殖相关蛋白Ki67表达对乳腺癌超声征象的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗选择乳腺癌患者组织标本124例，对相关生物样本的分析按照乳腺癌诊治规范进行。分析所有样本的超声征象，如肿块边缘、大小、形态、钙化区域、淋巴结转移、血流显像分级等；采用免疫组织化学法检测组织样本中P120ctn和Ki67的表达水平；分析其与乳腺癌超声征象的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗Ki67在乳腺癌组织中呈现阳性表达，P120ctn在乳腺癌组织中呈现阴性表达；在不同肿块直径和边缘存在毛刺的组织中，P120ctn和Ki67的表达水平差异均无统计学意义（P＞005），而在不同肿块形态、不同分布的微小钙化点、不同血流显像分级和发生淋巴结转移与否的组织中，P120ctn和Ki67的表达差异均有统计学意义（P＜005）。P120ctn蛋白和Ki67蛋白表达与超声征象中的肿块形态、微小钙化点分布、血流显像分级和淋巴结转移特点存在联系。Ki67和P120ctn蛋白表达之间呈正相关（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗超声征象与P120ctn蛋白和Ki67蛋白表达之间存在一定的联系，可以作为无创性预测乳腺癌患者P120ctn蛋白和Ki67蛋白表达的方式，〖JP2〗为乳腺癌恶变程度和预后的判断提供更多的依据。〖JP〗

关键词: 乳腺肿瘤, 连环蛋白, 核增殖相关蛋白

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the effect of P120ctn and Ki67 expression on breast cancer ultrasonography.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The breast cancer tissues of 124 patients with breast cancer who were examined and treated in our hospital. Analysis of the relevant biological samples was in accordance with the standard of diagnosis and treatment of breast cancer. The ultrasonic features of all the samples were analyzed, such as the edge, size, shape, calcification, lymph node metastasis, blood flow imaging and so on. The expression level of Ki67 and P120ctn in tissue samples was detected by immunohistochemical method, and their correlation with the ultrasonic features of breast cancer were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The expression of Ki67 in breast cancer tissues was positive, and the expression of P120ctn in breast cancer tissues was negative. There was no significant difference in the expression levels of P120ctn and Ki67 between the tissues with different diameters and edges(P＞005). However, the expression of P120ctn and Ki67 were significantly different in the tissues with different shape, different distribution of microcalcifications, different blood flow imaging grade and lymph node metastasis(P＜005). The expression of P120ctn protein and Ki67 protein was related to the shape of the tumor, the distribution of micro calcification, the grade of blood flow imaging and the characteristics of lymph node metastasis. The expression of P120ctn and Ki67 were negatively correlated(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The results showed that there was a certain relationship between ultrasonic signs and the expression of P120ctn protein and Ki67 protein. Ultrasonographic signs can be used as noninvasive prediction of the expression of P120ctn and Ki67 protein in patients with breast cancer to provide more evidence for the degree of malignancy and prognosis of breast cancer.

Key words: breast neoplasms, serial protein, nuclear proliferation related proteins

涂金晶，张〓鑫，刘〓青. 乳腺癌超声征象与P120ctn、Ki67表达水平的相关性[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.03.017.

TU Jinjing， ZHANG Xin, LIU Qing. Correlation between ultrasonic sign and the expression level of Ki67 and P120ctn in patients with breast cancer[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.03.017.

[1]	白紫合（综述）, 李娟, 吕雅蕾（审校）. Her2低表达晚期乳腺癌药物治疗的研究进展 [J]. 河北医科大学学报, 2023, 44(7): 860-865.
[2]	崔博, 张智翔, 解非, 李天云, 董军强, 魏梦绮. DCE-MRI与DWI在乳腺癌诊断中的应用及预后评估价值 [J]. 河北医科大学学报, 2023, 44(10): 1210-1215.
[3]	张摇, 付瑞环, 陆静, 马力. SPARC蛋白在乳腺癌组织中的表达及临床意义 [J]. 河北医科大学学报, 2022, 43(7): 768-774.
[4]	郑国红, 曹钢, 杨海芳, 米蕊, 王晓红. 放射治疗对乳腺癌患者心脏损伤指标影响的Meta分析[J]. 河北医科大学学报, 2022, 43(5): 530-535.
[5]	陈莉, 任玉艳, 韩凌, 张宝亮. 白蛋白与纤维蛋白原比值对乳腺癌预后的影响 [J]. 河北医科大学学报, 2022, 43(12): 1423-1427.
[6]	覃莉丽, 成宏, 匡思杰, 王开权. 剪切波弹性成像联合AKT1对判断局部晚期HER2阳性乳腺癌患者新辅助化疗效果及短期预后的预测价值[J]. 河北医科大学学报, 2022, 43(11): 1297-1301,1327.
[7]	赵若兰（综述）, 王影（审校）. 女性乳腺超声背景特征与乳腺癌关联性的研究进展 [J]. 河北医科大学学报, 2022, 43(11): 1351-1355.
[8]	郭奕阳, 马伟丽, 曹诗茹, 郭秀娟, 邓艳丽, 张金艳. 血清外泌体Glypican-1在乳腺癌中的表达水平及临床应用价值 [J]. 河北医科大学学报, 2022, 43(10): 1183-1187.
[9]	王婷婷, 赵一涵（综述）, 于杰 , 张洪珍（审校）. CCR8+Tregs：三阴性乳腺癌潜在治疗靶点 [J]. 河北医科大学学报, 2022, 43(10): 1220-1223.
[10]	吴晓, 刘佳妮, 彭鑫宇, 李晓明, 毛晶晶. 乳腺癌患者术后抑郁情绪的危险因素及临床预测模型的建立[J]. 河北医科大学学报, 2021, 42(8): 900-903,943.
[11]	吴安山, 艾红艳, 廖妮, 易坚胜, 谭米多. 免疫相关LncRNA与乳腺癌预后关系分析及预后风险模型建立[J]. 河北医科大学学报, 2021, 42(7): 789-794.
[12]	王鑫, 王锦辉, 王建华, 李甲, 柳浩然. 乳腺癌保乳术后放疗患者心理健康的影响因素分析[J]. 河北医科大学学报, 2021, 42(7): 795-798,836.
[13]	杨天宇（综述）, 吕雅蕾（审校）. microRNA在HER2阳性乳腺癌曲妥珠单抗耐药中的研究进展[J]. 河北医科大学学报, 2021, 42(5): 613-617.
[14]	李丽娜（综述），邓会岩，刘月平*（审校）. 乳腺癌多基因预后新时代[J]. 河北医科大学学报, 2020, 41(9): 1108-1112.
[15]	鲍双振, 杨进强, 王志超, 赵风龙, 尹长恒, 邢宏利. 阿托伐他汀早期干预绝经后乳腺癌患者的临床研究[J]. 河北医科大学学报, 2020, 41(8): 915-918,932.

乳腺癌超声征象与P120ctn、Ki67表达水平的相关性

Correlation between ultrasonic sign and the expression level of Ki67 and P120ctn in patients with breast cancer

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价