关键词: 白质软化症, 脑室周围, 胼胝体, 磁共振成像

Abstract: ［Abstract］  Objective〖HTSS〗〓To evaluate the changes in the corpus callosum of periventricular leukomalacia (PVL).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Forty cases of PVL（age 1-4 years old）and 40 cases of ageand sexmatched healthy children underwent conventional magnetic resonance imaging(MRI). The width of the corpus callosum genu and body, isthmus and splenium, the length of corpus callosum, area of corpus callosum， the effective area of the cranial cavity were measured.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The width of corpus callosum genu, body, isthmus, splenium, length, the area of corpus callosum, effective area of cranial cavity and normalized area of corpus callosum were lower than controls(P＜005).The width of corpus callosum genu, body, isthmus and splenium, the effective area of the cranial cavity,the area and normalized area of corpus callosum of moderate PVL group were less than mild(P＜0.05). There was no significant difference in the length of the corpus callosum between the mild and moderate PVL groups(P＞0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The corpus callosum appears to shrinks in varying degrees in children with PVL. The extent of the thinning of the corpus callosum in children with moderate PVL was larger than that of the mild PVL. Therefore, midsagittal of MRI can be used to measure the morphological changes of the corpus callosum in children with PVL, and can provide quantitative diagnosis for degree of PVL in children.

Key words: leukomalacia, periventricular, corpus callosum, magnetic resonance imaging