河北医科大学学报 ›› 2022, Vol. 43 ›› Issue (12): 1468-1473.doi: 10.3969/j.issn.1007-3205.2022.12.020

• • 上一篇    下一篇

血浆脂蛋白相关磷脂酶A2水平与颅内动脉粥样硬化斑块稳定风险的HR-MRI研究

  

  1. 陕西省人民医院MRI室，陕西 西安 710068

  • 出版日期:2022-12-25 发布日期:2023-01-11
  • 作者简介:严雪娇（1989-），女，陕西咸阳人，陕西省人民医院主治医师，医学硕士，从事脑血管病影像学研究。
  • 基金资助:
    国家自然科学基金面上项目（8217032354）；陕西省重点研发计划重点项目（2018ZDXM-SF-038）；陕西省重点研发计划一般项目（2021SF-064）

HR-MRI study of plasma lipoprotein-associated phospholipase A2 levels and the risk of intracranial atherosclerotic plaque stabilization

  1. Department of Magnetic Resonance Imaging, Shanxi Provinical People′s Hospital, Xi′an 710068, China
  • Online:2022-12-25 Published:2023-01-11

HTML

PDF (PC)

111

摘要： 目的 评估血浆脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2, Lp-PLA2)浓度水平与颅内斑块稳定特征之间的关系。
方法 回顾性纳入急性缺血性卒中患者83例。测定所有患者血浆Lp-PLA2浓度水平。利用高分辨率磁共振成像(high resolution magnetic resonance imaging,HR-MRI)测定颅内血管的狭窄率及斑块稳定特征，包括斑块强化、斑块表面是否规则及斑块内T1WI高信号；构建二分类Logistic回归模型，调整人口学及相关血脂混杂因素，评估高Lp-PLA2浓度水平与颅内斑块稳定特征之间的关系。
结果 高Lp-PLA2水平组患者中总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein, LDL)及血脂异常差异有统计学意义（P＜0.05）。在调整人口学及相关血脂因素后，Lp-PLA2浓度水平升高与斑块强化(P=0.005,OR=21.347，95%CI：2.645~177.604)和斑块表面不规则(P=0.044,OR=3.008，95%CI:1.030~8.780)独立相关。
结论 Lp-PLA2浓度水平升高与颅内斑块稳定性相关。


关键词: 斑块,动脉粥样硬化, 核磁共振成像, 血浆脂蛋白相关磷脂酶A2

Abstract: Objective To evaluate the relationship between plasma lipoprotein-associated phospholipase A2(Lp-PLA2) concentration and characteristics of intracranial atherosclerotic plaque stability. 
Methods Eighty-three patients with acute ischemic stroke (AIS)were retrospectively enrolled. Plasma Lp-PLA2 concentration was determined in all patients. High resolution magnetic resonance imaging(HR-MRI) was used to determine the stenosis rate of intracranial vessels and plaque stability characteristics, including plaque enhancement, regularity of the plaque surface and T1WI hyperintensity in the plaque. A binary Logistic regression model was established to evaluate the relationship between high LP-PLA2 concentration and characteristics of intracranial plaque stability by adjusting for demographic and related lipid confounders. 
Results There were significant differences in total cholesterol(TC), low density lipoprotein(LDL) and dyslipidemia in patients with high Lp-PLA2 level. After adjustment for demographic and related lipid factors, increased Lp-PLA2 concentration was independently associated with plaque enhancement (P=0.005,OR=21.347, 95%CI 2.645-177.604) and plaque surface irregularity (P=0.044,OR=3.008,95%CI 1.030-8.780). 
Conclusion Increased Lp-PLA2 concentration is associated with intracranial plaque stability.


Key words: plaque, atherosclerotic, high-resolution MRI, plasma lipoprotein-associated phospholipase A2

版权所有 © 《河北医科大学学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发