关键词: 周围神经损伤, 剖宫产术, 麻醉, 硬膜外, 地塞米松

Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the impact of timing of dexamethasone on nerve injury after cesarean section and inflammatory factors.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and twenty cases of nerve injury in our hospital undergoing epidural anesthesia for cesarean section in the process of puncturing patients were selected as the research objects. According to whether the application to dexamethasone and application time, the patients were divided into group A(dexamethasone using immediately after nerve injury), group B(dexamethasone using at surgery end time), group C(control group).Each group of tumor necrosis factorα(TNFα), interleukin1β(IL1β), interleukin6(IL6) level after 24 h, 48 h, 72 h and the nerve injury recovering were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There were no significant difference in operation time and intraoperative bleeding volume between the 3 groups(P＞005). The clinical efficacy of nerve root injury in group A and group B was better than that in group C, and the excellent rate was higher than that in group C(P＜005). The serum levels of TNFα, IL1β and IL6 increased gradually in the 3 groups, and the increased extent of group A were minimum, while the increased extent of group C were maximum. The differences of interaction among groups, time points, between groups and time points were statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Dexamethasone treating cesarean epidural puncturing nerve root injury is worthy of clinical application, and earlier application of dexamethasone could reduce the level of TNFα， IL1β， IL6, which indicates better clinical efficacy.
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Key words: peripheral nerve injuries, cesarean section, anesthesia, epidural, dexamethasone