河北医科大学学报

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脑梗死患者血清胱抑素C及D二聚体与颈动脉斑块稳定性的关系

  

  1. 河北省沧州市中心医院神经内四科，河北 沧州 061000
  • 出版日期:2017-12-25 发布日期:2017-12-19
  • 作者简介:曲明卫（1982-），男，河北沧州人，河北省沧州市中心医院主治医师，医学硕士，从事神经内科疾病诊治研究。
  • 基金资助:
    沧州市科技支撑计划项目（162302176）

Relationship between serum cystatin C and Ddimer and carotid plaque stability in patients with cerebral infarction

  1. The Fourth Department of Neurology, Cangzhou Central Hospital, Hebei Province, Cangzhou 061000, China
  • Online:2017-12-25 Published:2017-12-19

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨急性脑梗死患者中血清胱抑素C及D二聚体水平与颈动脉斑块稳定性的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗 选取急性脑梗死患者82例，并选取同期行健康体检的健康对照者65例，测定所有受试者的血清胱抑素C及D二聚体的水平，并应用彩色多普勒超声检测受试者的颈动脉内中膜厚度（intimamedia thickness，IMT）及动脉粥样硬化斑块性质，加以分析评价。
〖HTH〗结果〖HTSS〗〖KG*2〗脑梗死组血清胱抑素C及D二聚体水平显著高于对照组（P＜005）。IMT正常组和内膜增厚组血清胱抑素C水平低于斑块形成组,IMT正常组D二聚体水平低于斑块形成组,差异均有统计学意义（P＜005）。稳定斑块组血清胱抑素C水平低于不稳定斑块组，差异有统计学意义（P＜005）；2组D二聚体水平差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗血清胱抑素C水平除了与脑梗死的发生发展有关，还与颈动脉斑块的稳定性有着密切的关系；D二聚体水平在脑梗死早期升高,但与斑块稳定性的关系尚不明确。

关键词: 脑梗死, 胱抑素C, D二聚体, 斑块, 动脉粥样硬化

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the relationship between serum cystatin C and Ddimer levels and carotid plaque stability in patients with acute cerebral infarction.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 82 patients with acute cerebral infarction were enrolled in our hospital. Sixtyfive healthy controls were collected from our hospital. The levels of serum cystatin C and Ddimer were measured. The levels of carotid intimamedia thickness(IMT) and atherosclerotic plaque were measured by color Doppler ultrasonography.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of serum cystatin C and Ddimer in cerebral infarction group were significantly higher than those in control group(P＜005). The levels of cystatin C in IMT group and intimal thickening group were lower than those in plaque group, There was significant difference between the IMT group and the normal group(P＜005). The level of cystatin C in stable plaque group was lower than that in unstable plaque group, the difference was statistically significant(P＜005). There was no significant difference in Ddimer level between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Serum cystatin C levels are closely related to the development of cerebral infarction and the stability of carotid plaques, while Ddimer level is elevated in early stage of cerebral infarction, but with unclear relationship to plaque stability.

Key words: brain infarction, cystatin C, Ddimer； plaque, atherosclerotic

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