卡泊三醇软膏结合卤米松乳膏治疗银屑病的疗效及对患者皮肤屏障功能及血清瘦素、胃饥饿素表达的影响

doi:10.3969/j.issn.10073205.2018.01.018

河北医科大学学报

卡泊三醇软膏结合卤米松乳膏治疗银屑病的疗效及对患者皮肤屏障功能及血清瘦素、胃饥饿素表达的影响

江苏省泰州市第三人民医院皮肤科，江苏泰州 225321

出版日期:2018-01-25 发布日期:2018-01-05
作者简介:戴春燕（1971-），女，江苏泰州人，江苏省泰州市第三人民医院副主任医师，医学学士，从事皮肤科疾病诊治研究。

Effect of calcipotriol ointment combined with halometasone cream on the treatment of psoriasis and the influence on skin barrier function and expressions of ghrelin and serum leptin#br#

Department of Dermatology, the Third People′s Hospital of Taizhou City, Jiangsu Province, Taizhou 225321, China

Online:2018-01-25 Published:2018-01-05

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨卡泊三醇软膏结合卤米松乳膏治疗银屑病的效果以及对患者皮肤屏障功能和血清瘦素、胃饥饿素的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将96例银屑病患者随机分为观察组和对照组各48例，观察组应用卡泊三醇软膏与卤米松乳膏联合治疗，对照组单纯应用卡泊三醇软膏治疗；比较2组临床疗效以及治疗前和治疗6周后皮肤屏障功能、血清瘦素和胃饥饿素水平变化。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组总有效率为81.25%，对照组总有效率为54.17%，观察组疗效显著优于对照组(P＜005)。治疗后2组皮脂含量和角质层含水量显著升高，经表皮水分丢失显著减少(P＜005)；治疗后观察组皮脂含量和角质层含水量显著高于对照组，经表皮水分丢失显著低于对照组(P＜005)；治疗后2组血清瘦素及胃饥饿素水平均显著降低，观察组血清瘦素和胃饥饿素水平显著低于对照组(P＜005)。观察组不良反应率显著低于对照组(P＜005)。
〖HTH〗结论〖HTSS〗〖KG*2〗卡泊三醇与卤米松联合应用能够有效提高银屑病的疗效，改善皮肤屏障功能，降低血清瘦素和胃饥饿素水平，降低不良反应率。

关键词: 银屑病, 卡泊三醇, 卤米松, 瘦素

Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the effect of calcipotriol combined with halometasone on treating psoriasis and the influence on skin barrier function and serum leptin.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetysix patients with psoriasis were selected as the research object, all of them were randomly divided into observation group and control group, each group with 48 cases. The observation group was treated with calcipotriol combined with halometasone by sequential method, while control group was treated with calcipotriol only. The clinical effect, skin barrier function, serum leptin and chrelin before and after 6 week treatment were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The total effective rate of observation group was 81.25%, which was significantly higher than that of the control group 54.17%(P＜005). Before treatment, there was no different of sebum content, moisture content in stratum corneum and skin moisture loss between two groups, after treatment, the sebum content and moisture content of two groups were raised, the skin moisture loss were reduced significantly(P＜005). And the sebum content and moisture content of observation group were higher than control group(P＜005). The skin moisture loss was lower than control group significantly(P＜005). Before treatment, the serum leptin and ghrelin were not significantly different, the two targets of both group were reduced after treatment, and the observation group was significantly lower than control group(P＜005). The adverse reaction rate of observation group was significantly lower than control group(P<005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Calcipotriol combined with halometasone can effectively increase the effect on treating psoriasis, improve the skin barrier function, decrease serum leptin and ghrelin levels, decrease adverse reaction rate, which has a good effect on the treatment of psoriasis.

Key words: psoriasis, calcipotriol, halometasone, leptin

戴春燕，赵慧芳，戴长寅. 卡泊三醇软膏结合卤米松乳膏治疗银屑病的疗效及对患者皮肤屏障功能及血清瘦素、胃饥饿素表达的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.01.018.

DAI Chunyan， ZHAO Huifang， DAI Changyin. Effect of calcipotriol ointment combined with halometasone cream on the treatment of psoriasis and the influence on skin barrier function and expressions of ghrelin and serum leptin#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.01.018.

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卡泊三醇软膏结合卤米松乳膏治疗银屑病的疗效及对患者皮肤屏障功能及血清瘦素、胃饥饿素表达的影响

Effect of calcipotriol ointment combined with halometasone cream on the treatment of psoriasis and the influence on skin barrier function and expressions of ghrelin and serum leptin#br#

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