银离子敷料联合水凝胶治疗糖尿病足的效果及对相关血清炎症因子的影响

doi:10.3969/j.issn.10073205.2018.12.005

河北医科大学学报

银离子敷料联合水凝胶治疗糖尿病足的效果及对相关血清炎症因子的影响

1.中国人民解放军第四六三医院内分泌科，辽宁沈阳 110046；2.中国医科大学附属盛京医院乳腺外科，辽宁沈阳 110004

出版日期:2018-12-25 发布日期:2018-11-30
作者简介:金晓明(1981-)，女，锡伯族，辽宁沈阳人，中国人民解放军第四六三医院主治医师，医学硕士，从事内分泌疾病诊治研究。

Effects of silver ion dressing combined with hydrogel therapy on diabetic foot patients and serum inflammatory factors#br#

1.Department of Endocrinology, the 463rd Hospital of Chinese PLA, Liaoning Province, Shenyang
110046, China; 2.Department of Breast Surgery, the Affiliated Shengjing Hospital of
China Medical University, Liaoning Province, Shenyang 110004, China

Online:2018-12-25 Published:2018-11-30

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察银离子敷料联合水凝胶治疗糖尿病足的效果及对相关血清炎症因子的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗收集糖尿病足患者72例，随机分为观察组和对照组各36例。对照组给予湿疗伤口敷料联合水凝胶，观察组给予银离子敷料联合水凝胶。比较2组糖尿病足溃疡清创时间、肉芽组织生长时间、上皮组织形成时间，临床疗效和总有效率，治疗前后下肢动脉病变评分、血管内皮黏附分子1（vascular endothelial adhesion molecule1,VCAM1）、肿瘤坏死因子α（tumor necrosis factorα,TNFα）、白细胞介素6（interleukin6,IL6）、C反应蛋白（Creactive protein,CRP）水平。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组清创时间、肉芽组织形成时间和上皮组织形成时间均少于对照组，差异有统计学意义（P＜005）；观察组临床疗效和总有效率均优于或高于对照组（P＜005）；治疗后2组下肢动脉病变评分均低于治疗前，且观察组下肢动脉病变评分低于对照组，差异均有统计学意义（P＜005）；治疗后2组VCAM1、TNFα、CRP水平均低于治疗前，差异有统计学意义（P＜005），治疗后对照组IL6较治疗前升高，观察组治疗后IL6较治疗前降低，治疗后观察组VCAM1、TNFα、IL6及CRP水平低于对照组，差异均有统计学意义（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗银离子敷料联合水凝胶治疗糖尿病足较湿疗伤口敷料可进一步提高患者的临床疗效，改善下肢动脉病变，其作用机制可能与清除血清炎症因子有关。

关键词: 糖尿病足, 银离子敷料, 水凝胶, 血清炎症因子

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the effects of silver ion dressing combined with hydrogel therapy on patients with diabetic foot and serum inflammatory factors.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 72 patients with the diabetic foot were collected and divided into the observation group(n=36) and the control group(n=36) randomly. The control group were given wet wound dressing combined with hydrogel, while the observation group were treated with silver ion dressing combined with hydrogel. The debridement time for diabetic foot ulcers, granulation tissue growth time, epithelial tissue formation time, the curative effects and total effective rate, the lower extremity arterial disease score, vascular endothelial adhesion molecule1(VCAM1), tumor necrosis factorα(TNFα), interleukin6(IL6), C reactive protein(CRP) levels of two groups before and after treatment were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The debridement time, granulation tissue formation time and the granulation tissue growth time in the observation group were lower than the control group(P＜005). The total effective rate of the observation group was 91.7%, which was higher than the control group(72.2%)(P＜005). There was no significant difference between the two groups of the lower extremity arterial disease score before treatment(P＞005). After treatment, the lower extremity arterial disease score of the two groups was lower than pretreatment(P＜005), and the lower extremity arterial disease score in the observation group was lower than the control group(P＜005). There was no significant difference between two groups in VCAM1, 〖JP2〗TNFα, IL6 and CRP levels before treatment(P＞005). After treatment, the VCAM1, TNFα,〖JP〗 IL6 and CRP levels of the two groups were lower than pretreatment(P＜005), and the VCAM1, TNFα, IL6 and CRP levels in the observation group were lower than the control group(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Compared with wet wound dressing, silver ion dressing combined with hydrogel therapy on the patients with diabetic foot could improve the clinical efficacy and the lower extremity arterial disease, which may be related to the clearance of serum inflammatory factors and worth extensive clinical application.

Key words: diabetic foot, silver ions dressing, hydrogel, serum inflammatory factors

金晓明1，韩思佳2，吴雁翔1*. 银离子敷料联合水凝胶治疗糖尿病足的效果及对相关血清炎症因子的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.12.005.

JIN Xiaoming1， HAN Sijia2， WU Yanxiang1*. Effects of silver ion dressing combined with hydrogel therapy on diabetic foot patients and serum inflammatory factors#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.12.005.

[1]	林杨, 杨伟光, 张滨, 王丽丽, 李婷婷, 王旭红. 不同严重程度糖尿病足细菌感染特征与下肢血管病变及病情结局的关系[J]. 河北医科大学学报, 2021, 42(7): 784-788.
[2]	贺银习, 陈彦霞, 许英, 郭宇松, 田利军, 刘品力. 横向骨搬移技术联合PRP对糖尿病足患者血清因子的影响[J]. 河北医科大学学报, 2020, 41(8): 940-943.
[3]	张亮，张继春，庞子轩，王玉冰. 负压吸引联合前列地尔及依帕司他治疗糖尿病足部溃疡的临床研究[J]. 河北医科大学学报, 2020, 41(5): 532-535.
[4]	杨立娜，张翠兰，侯书鹏，丁〓萌，解少伟，弓丽敏. 426例糖尿病足住院患者临床特征分析#br#[J]. 河北医科大学学报, 2019, 40(3): 347-350.
[5]	王富军. 中国糖尿病足防治指南（2019版）解读#br#[J]. 河北医科大学学报, 2019, 40(11): 1241-1245,1250.
[6]	王虹1，张洁2，牛丽霞3，王伟超4，胡雅萍5，刘富德5. 预见性护理对老年糖尿病足患者的影响[J]. 河北医科大学学报, 2017, 37(6): 650-653.
[7]	吕晓静;张趁儒;王郡;杜丽娜;陈志花;李奉. 对糖尿病足合并抑郁患者实施健康教育和心理干预的效果观察[J]. , 2014, 35(6): 688-688.
[8]	苏文昭;王冬梅;任平香;张秀香;张学清. 心理干预对糖尿病足患者血糖和C反应蛋白的影响[J]. , 2013, 34(7): 843-843.
[9]	谭东;郭玉妍;吕素君. 透明水凝胶敷料在颅脑损伤患者眼部的应用体会[J]. , 2013, 34(6): 0-0.
[10]	赵玲玲;韩书明;蔡俊刚;李莉;郭海涛. 加用中药外洗治疗糖尿病足108例临床观察[J]. , 2011, 32(7): 767-767.
[11]	於丽红;张松筠;苏胜偶;杨俊花. 新型敷料治疗不同类型糖尿病足的疗效观察[J]. , 2009, 30(5): 497-497.
[12]	杨亚兰;王静;张贵敏. 亲水凝胶制剂的研究与应用[J]. , 2005, 26(2): 159-159.

银离子敷料联合水凝胶治疗糖尿病足的效果及对相关血清炎症因子的影响

Effects of silver ion dressing combined with hydrogel therapy on diabetic foot patients and serum inflammatory factors#br#

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 12

编辑推荐

Metrics

本文评价