慢性阻塞性肺疾病不同亚型肺气肿与肺功能的相关性研究

doi:10.3969/j.issn.10073205.2018.12.014

河北医科大学学报

慢性阻塞性肺疾病不同亚型肺气肿与肺功能的相关性研究

1.河北医科大学第一医院放射科，河北石家庄 050031；2.河北医科大学第一医院核医学科，河北石家庄 050031；
3.河北医科大学第一医院呼吸科，河北石家庄 050031

出版日期:2018-12-25 发布日期:2018-11-30
作者简介:何丽（1980-），女，河北石家庄人，河北医科大学第一医院副主任医师，医学硕士，从事医学影像诊断研究。
基金资助:
河北省医学科学研究重点课题（20170065）

Study on the correlation between different subtypes of emphysema and pulmonary function in chronic obstructive pulmonary disease#br#

1.Department of Radiology, the First Hospital of Hebei Medical University,Shijiazhuang 050031,China；
2.Department of Nuclear Medicine, the First Hospital of Hebei Medical University, Shijiazhuang
050031, China； 3.Department of Respiratory Medicine, the First Hospital of
Hebei Medical University, Shijiazhuang 050031, China

Online:2018-12-25 Published:2018-11-30

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）不同病理类型肺气肿与肺功能检查(pulmonary function test，PFT)指标的相关性。
〖HTH〗方法〖HTSS〗〖KG*2〗选择临床确诊为COPD肺气肿患者42例，行多排螺旋 CT(multislice helical CT,MSCT)及肺功能检查。根据MSCT特点将其分为小叶中心型肺气肿(centrilobular emphysema,CLE)组28例、全小叶型肺气肿(panlobular emphysema,PLE)组14例，肺气肿定量分析软件自动测量出肺气肿指数(percentages of low attenuation volume，LAV%)，采用肺功能仪检测PFT指标［第1秒用力呼气容积(forced expiratory volume in 1 second,FEV1)实测值与预测值的百分比(percentage of the forced expiratory volume in 1 second predicted value,FEV1%)、FEV1/用力肺活量（forced vital capacity,FVC）、残气量与肺总量比（residual volume/total lung capacity,RV/TLC）和一氧化碳弥散量（percentage of the diffusing capacity for carbon monoxide per liter of lung volume predicted value,DLco%）］，比较2组LAV%和PFT指标。分析LAV%与PFT指标的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗CLE组两肺、右肺、右肺上叶、右肺中叶、右肺下叶、左肺、左肺上叶、左肺下叶LAV%均低于PLE组，DLco%显著高于PLE组（P＜005）；2组FEV1%、FEV1/FVC及RV/TLC差异均无统计学意义（P＞005）。两肺、右肺、右肺上叶、右肺中叶、右肺下叶、左肺、左肺上叶、左肺下叶LAV%与FEV1/FVC呈负相关（P＜005），两肺、右肺、右肺上叶、右肺下叶、左肺、左肺上叶、左肺下叶LAV%与DLco%呈负相关（P＜005）；两肺、右肺、右肺上叶、右肺中叶、右肺下叶、左肺、左肺上叶、左肺下叶LAV%与FEV1%和RV/TLC无相关性（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗CLE组DLco%显著高于PLE组，CT肺气肿指数与肺功能参数有一定的相关性，通过CT特征对肺气肿进行分类可为肺气肿患者的个性化治疗提供一定的帮助。

关键词: 肺疾病, 慢性阻塞性, 肺气肿, 呼吸功能试验

Abstract: ［Abstract］〓Objective〖HTSS〗〓To explore the correlation between pulmonary emphysema and pulmonary function test(PFT) in different pathological types of chronic obstructive pulmonary disease(COPD).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 42 patients with clinically confirmed COPD emphysema were selected. In the present study，pulmonary emphysema was divided into the following 2 subtypes according to MSCT feature: centrilobular emphysema(CLE) group(n=28)and panlobular emphysema(PLE)group(n=14). The percentage of lower attenuation voxel volume(LAV%) was automatically measured with quantitative analysis software which was pulmonary emphysema index for the total lung and each lobar. The forced expiratory volume in 1 second predicted(FEV1%), the ratio of forced expiratory volume in 1 second over forced vital capacity(FEV1/FVC) , the ratio of residual volume to total lung capacity ratio(RV/TLC) and percentage of the diffusing capacity for carbon monoxide per literof lung volume predicted value（DLco%） were measured using spirometer.The correlation between LAV% and PFT index were analyzed in 42 patients with emphysema.LAV% and PFT index were compared between different groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓LAV% of both lung and each lobar in CLE group was statistically lower than PLE group( P＜005)，and DLco% of both lung and each lobar in CLE group was statistical higher than PLE group(P＜005). There were no difference between CLE and PLE groups for FEV1%, FEV1/FVC and RV/TLC(P＞005) . LAV% of both lungs ，left lung，right lung and each lobar were negatively correlated with FEV1/FVC(P＜005）. Apart from right middle lobar，LAV% of both lungs，left lung，right lung and each lobar were negatively correlated with DLco%（P＜005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓DLco% in CLE group was statistically higher than PLE group. LAV% were correlated with the PFT index. The subtype according to the CT features was helpful for the individualized treatment of pulmonary emphysema in COPD.

Key words: pulmonary disease, chronic obstructive, pulmonary emphysema, respiratory function tests

何〓丽1，刘〓斋1*，贾立镯2，母建奎1，李〓珠3，任庆云1. 慢性阻塞性肺疾病不同亚型肺气肿与肺功能的相关性研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.12.014.

HE Li1, LIU Zhai1*, JIA Lizhuo2, MU Jiankui1, LI Zhu3, REN Qingyun1. Study on the correlation between different subtypes of emphysema and pulmonary function in chronic obstructive pulmonary disease#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.12.014.

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慢性阻塞性肺疾病不同亚型肺气肿与肺功能的相关性研究

Study on the correlation between different subtypes of emphysema and pulmonary function in chronic obstructive pulmonary disease#br#

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