河北医科大学学报

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白细胞介素4 rs2070874基因多态性与H.pylori感染及胃癌易感性的关系

  

  1. 1.河北医科大学第二医院检验科，河北 石家庄 050000；2.河北医科大学第二医院医学影像科，河北 石家庄 050000
  • 出版日期:2018-12-25 发布日期:2018-11-30
  • 作者简介:郭欣（1974-），女，河北行唐人，河北医科大学第二医院副主任检验师，医学博士后，从事临床检验学研究。
  • 基金资助:
    河北省医学科学研究重点课题(20160526)；河北省自然科学基金项目(H2014206117)

Relationship analysis of interleukin 4 rs2070874 gene polymorphism with H.pylori infection and susceptibility to gastric cancer#br#

  1. 1.Department of Laboratory Medicine， the Second Hospital of Hebei Medical University, Shijiazhuang
    050000, China； 2.Department of Medical Image， the Second Hospital of Hebei
    Medical University, Shijiazhuang 050000, China
  • Online:2018-12-25 Published:2018-11-30

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨河北汉族成年人群中白细胞介素4（interleukin4,IL4）rs2070874基因型及其基因频率与幽门螺杆菌（H.pylori）感染、胃癌临床易感性的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗收集本院就诊患者分为3组：H.pylori感染组105例，未感染组103例，胃癌组103例。留取患者外周静脉血，采用直接测序法对IL4 rs2070874进行基因型测定。
〖HTH〗结果〖HTSS〗〖KG*2〗IL4 rs2070874基因型在H.pylori感染组以TT型为主（55.24%），胃癌组以TC型为主（55.34%），未感染组以TT型为主（44.66%）；胃癌组TC基因型高于H.pylori感染组和未感染组，基因型分布差异有统计学意义（P＜005），而H.pylori感染组与未感染组基因型分布差异无统计学意义。3组人群该位点均以T基因为高表达基因，3组人群T、C等位基因频率差异无统计学意义（P＞005）。该位点C为低频率表达基因，表达频率为0.321 5。
〖HTH〗结论〖HTSS〗〖KG*2〗IL4 rs2070874基因多态性与胃癌易感性有关，而与H.pylori感染无关，该位点TC基因型可能增加胃癌风险。

关键词: 胃肿瘤, 白细胞介素4, 幽门螺杆菌

Abstract: ［Abstract］ Objective〖HTSS〗〓 To evaluate the relationship of interleukin4（IL4） rs2070874 gene polymorphism with H.pylori infection and susceptibility to gastric cancer in different groups of the Han nationality adults.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 311 subjects were recruited and divided into three groups: 105 H. pylori positive, 103 gastric cancer people, and 103 H. pylori negative. The peripheral venous bloods were extracted and direct sequencing method were used for IL4 rs2070874 gene polymorphism analysis. 
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The main genotype of IL4 rs2070874 in H. pylori infection group was TT type, accounting for 55.24% of the total, TC type was the main genotype in gastric cancer group, accounting for 55.34% of the total, and TT type was the main genotype in noninfection group, accounting for 44.66% of the total. TC genotype in gastric cancer group was higher than that in H. pylori infection group and noninfection group, and the genotype distribution had significant difference(P＜001).But no significant difference was found between H. pylori positive and negative group. T was the high expression gene of this locus and no different frequency was founded in the three groups(P＞005). The C frequency of IL4rs2070874 in Han nationality adults was 0.3215.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓IL4 rs2070874 gene polymorphism may be associated with gastric cancer susceptibility, but not with H. pylori infection, TC gene may increase the risk of gastric cancer.

Key words: stomach neoplasm, interleukin4, helicobacter pylori

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