河北医科大学学报

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参麦注射液在脓毒症心肌损伤患者中的作用#br#

  

  1. 1.河北省人民医院重症医学科，河北 石家庄 050051；2.河北省平山县医院呼吸科，河北 平山 050400；3.河北省胸科医院结核三病区，河北 石家庄 050041
  • 出版日期:2019-07-25 发布日期:2019-07-16
  • 作者简介:何聪（1982-），女，河北衡水人，河北省人民医院主治医师，医学硕士，从事重症医学研究。
  • 基金资助:
    河北省中医药管理局科技计划项目(2015144）

Effect of Shenmai injection on sepsis patients with myocardial injury#br#

  1. 1.Department of ICU, Hebei General Hospital, Shijiazhuang 050051， China; 2.Department of
    Respiratory Medicine, Pingshan County Hospital, Hebei Province, Pingshan 050400, China；
    3.Tuberculosis Three Districts, Hebei Chest Hospital, Shijiazhuang 050041, China
  • Online:2019-07-25 Published:2019-07-16

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨参麦注射液对脓毒症心肌损伤患者的心脏保护作用。
〖HTH〗方法〖HTSS〗〖KG*2〗选择诊断为脓毒症心肌损伤的患者32例，均行有创性血流动力学监测及超声监测，指导液体复苏，均给予规范的常规集束化治疗(抗感染、呼吸及循环支持等)。随机将32例患者分为2组各16例。对照组采用规范的集束化治疗；治疗组采用规范的集束化治疗+参麦注射液200 mL，每日1次，连续7 d。
〖HTH〗结果〖HTSS〗〖KG*2〗2组第1天、第4天间脑钠素（brain natriuretic peptide,BNP）和肌钙蛋白I（troponin I，cTnI）水平差异均无统计学意义（P＞005），治疗组第7天BNP和cTnI水平高于对照组，差异有统计学意义（P＜005）；随时间延长，2组肌酸激酶同工酶（creatine kinase isoenzyme MB，CKMB）水平均有下降，但2组第1天、第4天和第7天CKMB水平差异均无统计学意义（P＞005）。2组心电图好转率差异无统计学意义(P＞005)。2组住ICU时间、28 d病死率差异均无统计学意义(P＞005)。
〖HTH〗结论〖HTSS〗〖KG*2〗参麦注射液对脓毒症心肌损伤患者心肌可起到一定的保护作用。

关键词: 脓毒症, 心肌损伤, 参麦注射液

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the cardioprotective effect of Shenmai injection in patients with sepsis and myocardial injury.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirtytwo patients with myocardial injury due to sepsis were selected. All patients underwent invasive hemodynamic monitoring and ultrasound monitoring to guide fluid resuscitation. All patients were given standard conventional bundle therapy(antiinfection, respiratory and circulatory support, etc.).32 patients were randomly divided into 2 groups,16 cases per group. The control group: standard bundle treatment.Treatment group: standardized bundle therapy + Shenmai injection 200 mL, once daily for 7 days.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference in brain natriuretic peptide(BNP) level and troponin I(cTnI) level between two groups on day 1 and day 4(P＞005). The level of BNP and cTnI in the treatment group on day 7 was higher than that in the control group, and the difference was statistically significant(P＜005). The creatine kinase isoenzyme MB(CKMB) level in both groups decreased with time, but the level of CKMB in the two groups on day 1, 4 and 7 decreased.There was no statistically significant difference in the improvement rate of ECG between two groups(P＞005). There was no statistically significant difference in the length of ICU stay and 28day mortality between two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Shenmai injection can protect the myocardium of patients with sepsis myocardial injury.

Key words: sepsis, myocardial injury, Shenmai injection

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