关键词: 子宫腺肌瘤, 促性腺激素释放激素激动剂, 左炔诺孕酮

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the clinical efficacy of gonadotropin release hormone agonist(GnRHa） combined with levonorgestrel releasing intrauterine system(LNGIUS) in the hysteroscopic treatment of uterine adenomyoma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Fifteen cases of uterine adenomyoma who underwent hysteroscopic resection combined with GnRHa and LNGIUS treatment were selected. The operation time, intraoperative and postoperative complications were recorded. The improvement of dysmenorrhea， the changes of menstrual volume, uterine volume and the relapse of uterine adenomyoma were compared before and after surgery.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓All patients completed the operation successfully. The operation time was 38-75 min, with an average of 46.3 min，and there was no intraoperative or postoperative complications. Postoperative followup lasted for 12 months,with the extension of time, the menstrual score and VRS score showed a gradually decreasing trend, and the uterine volume, hemoglobin and serum CA125 level also showed a decreasing trend, slightly increased at 12 months after treatment. The difference was statistically significant(P＜0.05). After operation, 2 cases had much more vaginal discharge than before, 4 caseshad a bit of vaginal bleeding, 1 case mirena fallen off, 1 case had weight increase, 1 case had ovarian cyst.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The effect of GnRHa combined with LNGIUS is significant in the hysteroscopic treatment of uterine adenomyoma.

Key words: uterine adenomyoma, gonadotropin releasing intrauterine system, levonorgestrel