›› 2015, Vol. 36 ›› Issue (2): 148-148.

• 论文 • 上一篇    下一篇

结核感染T细胞检测在骨关节结核中的诊断价值

贾晨光;姚黎明;李秀武;刘丰胜;章志华;张金文   

  1. 河北省胸科医院骨科,河北 石家庄,050041%河北省胸科医院病理科,河北 石家庄,050041%河北省胸科医院科教处,河北 石家庄,050041
  • 发布日期:2015-02-25

WU Tao;CUI Yun-wei;ZHANG Qi;CHEN Wei;LI Sheng;ZHANG Ying-ze

JIA Chen-guang;YAO Li-ming;LI Xiu-wu;LIU Feng-sheng;ZHANG Zhi-hua;ZHANG Jin-wen   

  • Published:2015-02-25

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摘要： 目的：评价结核感染T细胞检测（tuberculous infection of T cells spot test，T-SPOT．TB）在疑似骨关节结核病中的诊断价值。方法选取80例确诊为骨关节结核患者和44例排除结核患者。分别进行抗酸染色、结核菌培养、实时荧光定量 PCR 检测及 T-SPOT．TB，比较并分析检测结果。结果 T-SPOT．TB 的敏感度、特异度和准确度分别为82．5％、75．0％、79．8％。T-SPOT．TB 的阳性检出率显著高于抗酸染色、结核分枝杆菌培养（P ＜0．05），而在不同疾病部位（脊柱、四肢关节）及不同病程分组间阳性检出率差异无统计学意义（P ＞0．05）。结论 T-SPOT．TB 可以作为骨关节结核病的重要辅助诊断方法。

关键词: 结核, 骨关节, 结核感染T细胞检测, 诊断

Abstract: Objective To investigate the value of tuberculous infection of T cells spot test (T-SPOT.TB)in the diagnosis of osteoarticular tuberculosis.Methods The study enrolled 80 patients who were confirmed osteoarticular tuberculosis and 44 did not have active tuberculosis. Acid-fast staining,mycobacterial culture,real-time quantitative PCR were respectively performed for the patients.The results were compared and analyzed.Results The sensitivity,specificity, accuracy for osteoarticular tuberculosis diagnosis by T-SPOT.TB assay were 82.5%,75.0% and 79.8%.The positive rate of T-SPOT.TB was significantly higher than that of acid-fast staining, mycobacterial culture(P < 0.05).But,there were no statistical difference in different locations (spine or extremities joint)and courses between groups.Conclusion The results suggested that T-SPOT.TB assay could provide useful aids in the diagnosis of osteoarticular tuberculosis.

Key words: tuberculosis, osteoarticular, tuberculous infection of T cells spot test, diagnosis

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