左甲状腺素片及生长激素在治疗甲状腺功能减退导致矮小症中的临床效果观察

doi:10.3969/j.issn.10073205.2019.01.007

河北医科大学学报

左甲状腺素片及生长激素在治疗甲状腺功能减退导致矮小症中的临床效果观察

河北省石家庄市第一医院内分泌一科，河北石家庄 050011

出版日期:2019-12-25 发布日期:2018-12-29
作者简介:吴韬（1973-），女，河北石家庄人，河北省石家庄市第一医院主任医师，医学硕士，从事内分泌疾病诊治研究。
基金资助:
石家庄市科学技术研究与发展指导计划（161460683）

The clinical efficacy of levothyroxine and growth hormone in the treatment of dwarfism caused by hypothyroidism

The First Department of Endocrinology， the First Hospital of Shijiazhuang， Hebei Province， Shijiazhuang 050011， China

Online:2019-12-25 Published:2018-12-29

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察左甲状腺素片及生长激素在治疗甲状腺功能减退导致矮小症中的临床效果。
〖HTH〗方法〖HTSS〗〖KG*2〗选择确诊为甲状腺功能减退症导致的矮小症患儿80例，将患儿随机分为对照组（左甲状腺素片治疗）和试验组（左甲状腺素片+生长激素治疗）各40 例。比较2组治疗前和治疗后 3 个月、6 个月生长速度（growth velocity，GV）、身高标准差积分（height standard deviation score，HtSDS）、预测成年身高（prediction of adultheight，PAH）、骨龄（bone age,BA）、血清骨钙素（osteocalcin,OC）水平。记录治疗前后血清甲状腺激素（thyroxine,T4）水平变化情况。
〖HTH〗结果〖HTSS〗〖KG*2〗2组治疗后GV、HtSDS、PAH、OC水平均随时间逐渐升高，在治疗 3 个月时 GV、HtSDS、PAH、OC水平无显著差异，治疗 6 个月时试验组 GV、HtSDS、PAH、OC水平明显高于对照组，其组间、时点间、组间·时点间交互作用差异均有统计学意义（P＜005）。2组BA组间、时点间、组间·时点间交互作用差异均无统计学意义（P＞005）。 2组治疗后 3个月T4水平均明显升高，其时点间差异有统计学意义（P＜005），而其组间、组间·时点间交互作用差异均无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗左甲状腺素片联合重组人生长激素治疗甲状腺功能减退导致的矮小症患儿，可以促进其身高的增长，显著提高其甲状腺激素水平。

关键词: 生长障碍, 甲状腺素, 生长激素

Abstract: ［Abstract］〓Objective〖HTSS〗〓To study the exact effect of levothyroxine and growth hormone in the treatment of dwarfism caused by hypothyroidism.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eighty children with short stature caused by hypothyroidism were selected and randomly divided into control group(levothyroxine tablet treatment) and experimental group(levothyroxine tablet + growth hormone treatment) according to different treatment methods, 40 cases in each group. Growth velocity(GV), height standard deviation score(HtSDS), predicted adult height(PAH), bone age(BA) and serum osteocalcin(OC) levels were compared before and after treatment for 3 and 6 months. The changes of serum thyroxine(T4) levels were recorded before and after treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of GV, HtSDS, PAH and OC increased with time after treatment. There was no significant difference in GV, HtSDS, PAH and OC levels at 3 months of treatment. At 6 months of treatment, GV, HtSDS, PAH and OC levels in the experimental group were significantly higher than those in the control group. There were significant differences in the interactions among groups, time points, and between groups（P＜005）. There was no significant difference in the interaction between BA groups, time points and grouptime point interaction P＞005). T4 levels in both groups increased significantly after 3 months of treatment(P＜005). However, there was no significant difference in the interaction between T4 groups, between groups and between time points after treatment P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Levothyroxine combined with recombinant human growth hormone in the treatment of dwarfism caused by hypothyroidism can effectively promote the growth of height, and significantly increase the level of thyroid hormone.

Key words: growth disorders, thyroxine, growth hormone

吴〓韬，杜俊文*，张〓坤，任巧华，王〓欣，梁〓屹. 左甲状腺素片及生长激素在治疗甲状腺功能减退导致矮小症中的临床效果观察[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.01.007.

WU Tao, DU Junwen*, ZHANG Kun, REN Qiaohua, WANG Xin, LIANG Yi. The clinical efficacy of levothyroxine and growth hormone in the treatment of dwarfism caused by hypothyroidism[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.01.007.

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左甲状腺素片及生长激素在治疗甲状腺功能减退导致矮小症中的临床效果观察

The clinical efficacy of levothyroxine and growth hormone in the treatment of dwarfism caused by hypothyroidism

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