神经电生理指标与糖尿病周围神经病变病情分级的相关性分析

doi:10.3969/j.issn.10073205.2019.02.010

河北医科大学学报

神经电生理指标与糖尿病周围神经病变病情分级的相关性分析

中国康复研究中心北京博爱医院内分泌科，北京 100068

出版日期:2019-02-25 发布日期:2019-01-16
作者简介:戚艳艳（1981-），女，山东烟台人，中国康复研究中心北京博爱医院主治医师，医学硕士，从事内分泌疾病诊治研究。
基金资助:
中央级公益性科研院所基本科研业务费专项资金项目（2014CZ27）

Analysis of the relationship between the electrophysiological indexes and the classification of diabetic peripheral neuropathy#br#

Department of Endocrinology, Beijing Bo′ai Hospital of China Rehabilitation Research Center, Beijing 100068, China

Online:2019-02-25 Published:2019-01-16

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨神经电生理指标与糖尿病周围神经病变(diabetic peripheral neuropathy，DPN)病情分级的相关性。
〖HTH〗方法〖HTSS〗〖KG*2〗选择DPN患者90例作为观察组，健康体检者90例作为对照组，检测2组运动神经传导速度、远端潜伏期、波幅，记录皮肤交感反应(sympathetic skin response,SSR)、上肢躯体感觉诱发电位(somatosensory evoked potential，SEP)和下肢SEP异常率。判定DPN分级情况，分析病情分级与神经电生理指标的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗观察组运动神经传导速度、波幅明显小于对照组，远端潜伏期以及SSR、上肢SEP、下肢SEP异常率较对照组明显增加(P＜005)。DPN患者中Ⅰ级45例，Ⅱ级20例，Ⅲ级15例，Ⅳ级10例。随着DPN病情加重，运动神经传导速度、波幅均明显减小，远端潜伏期以及SSR、上肢SEP、下肢SEP异常率均明显增加 (P＜005)。DPN病情分级与运动神经传导速度、波幅呈负相关，与远端潜伏期、SSR、上肢SEP和下肢SEP呈正相关(P＜005)。
〖HTH〗结论〖HTSS〗〖KG*2〗神经电生理指标可提高DPN的确诊率，并反映患者的病情状况，有助于DPN的早期发现和治疗。

关键词: 糖尿病神经病变, 病情分级, 神经电生理

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the correlation between neurophysiological parameters and the classification of diabetic peripheral neuropathy(DPN).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 90 patients with DPN were selected as the observation group, and 90 healthy subjects were used as the control group. The motor nerve conduction velocity, distal latency and amplitude were measured. The sympathetic skin response(SSR), upper limb somatosensory evoked potential(SEP) and lower limb SEP abnormalities were recorded. The DPN grading situation was determined and the correlation between disease grading and neurophysiological indicators was analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The motor nerve conduction velocity and amplitude of the observation group were significantly lower than those of the control group. The abnormal rate of distal latency, SSR, upper limb SEP and lower limb SEP was significantly higher than that of the control group(P＜005). Among the 90 patients with DPN, 45 patients were grade Ⅰ, 20 patients were grade Ⅱ, 15 patients were grade Ⅲ, and 10 patients were grade Ⅳ. With the aggravation of DPN, the motor nerve conduction velocity and amplitude were significantly reduced, and the abnormal rates of distal latency, SSR, upper limb SEP and lower limb SEP were significantly increased(P＜005). The grade of DPN were negatively correlated with motor nerve conduction velocity and amplitude, and were positively correlated with distal latency, SSR, upper limb SEP and lower limb SEP(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The application of neurophysiological indicators in patients with DNP can improve the diagnosis rate of DPN, reflect the patient's condition and contribute to the early detection and treatment of DPN.

Key words: diabetic neuropathies, disease grading, neuroelectrophysiology

戚艳艳. 神经电生理指标与糖尿病周围神经病变病情分级的相关性分析[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.02.010.

QI Yanyan. Analysis of the relationship between the electrophysiological indexes and the classification of diabetic peripheral neuropathy#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.02.010.

[1]	张桐毓, 杨传慧, 徐宁. 糖尿病周围神经病变炎症因子变化及与神经传导速度相关性 [J]. 河北医科大学学报, 2023, 44(5): 517-520,571.
[2]	于冬, 温莉, 张涛, 郭妍, 金城, 孟现军. 2型糖尿病胫神经病变超声特征的ROC曲线分析[J]. 河北医科大学学报, 2021, 42(9): 1032-1036.
[3]	罗妮娅1，张力辉2*，张成量1，袁〓娜1，刘树科3，阴〓丽1. 小剂量6542联合川芎嗪治疗糖尿病周围神经病变临床效果观察[J]. 河北医科大学学报, 2019, 40(5): 516-520,524.
[4]	吕淑娟1，邹吉敏2，苏盈莹2，郑俊忠3，元小冬1，丁焕然4. 121例糖尿病患者神经电生理分析[J]. 河北医科大学学报, 2016, 37(6): 640-643.
[5]	刘宪红1，靳妍霞1，牛金葆2，丰慧慧3，吴绍华4，孙秀全5. 高压氧联合普瑞巴林治疗痛性糖尿病周围神经病变的临床研究[J]. 河北医科大学学报, 2016, 37(11): 1246-1249.
[6]	李艳君;冯彦景;查月芳. 10g单丝在糖尿病周围神经病变筛查中的价值[J]. , 2015, 36(8): 884-884.
[7]	李艳君;孙金昊(综述);冯彦景;路惠民(审校). 痛性糖尿病周围神经病变[J]. , 2014, 35(8): 986-986.
[8]	倪海霞;郭建东;赵海军. 硫辛酸联合甲钴胺对2型糖尿病心脏自主神经病变患者心率变异性的影响[J]. , 2014, 35(3): 312-312.
[9]	张艳町;牛久欣;张秋娅;张海丽;吴霞. α-硫辛酸与前列地尔、甲钴胺联合治疗糖尿病周围神经病变的临床研究[J]. , 2014, 35(2): 133-133.
[10]	韩瑞平;谷春芳. 硫辛酸对糖尿病周围神经病变的疗效观察[J]. , 2012, 33(9): 1056-1056.
[11]	邱轩. 糖尿病神经病变及神经性疼痛的治疗进展[J]. , 2012, 33(11): 1351-1351.
[12]	陈贵言;魏锋;孙迎俊;崔璐. 马来酸桂哌齐特联合甲钴胺治疗糖尿病周围神经病变临床观察[J]. , 2010, 31(4): 440-440.

神经电生理指标与糖尿病周围神经病变病情分级的相关性分析

Analysis of the relationship between the electrophysiological indexes and the classification of diabetic peripheral neuropathy#br#

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 12

编辑推荐

Metrics

本文评价