关键词: 胸痛, 心型脂肪酸结合蛋白, 微小RNA-21, 生长分化因子-15

Abstract: Objective To analyze the predictive value of heart-type fatty acid binding protein(H-FABP), microRNA-21(miRNA-21), and growth differentiation factor-15(GDF15) in acute chest pain. 
Methods In total, 600 patients with acute chest pain were selected as the observation group, and 600 healthy people undergoing physical examination during the same period were selected as the control group. The enzyme-linked immunosorbent assay(ELISA) was used to detect the serum H-FABP, miRNA-21, and GDF15 of subjects in the two groups.Receiver operating characteristics curve(ROC) was used for analysis of the predictive value of H-FABP, miRNA-21, and GDF15 in acute chest pain. 
Results The levels of H-FABP, GDF15 and miRNA-21 in the acute chest pain group were higher than those in the control group(P＜0.05). Compared with those of mild patients, the levels of H-FABP, miRNA-21 and GDF15 increased in moderate and severe patients(P＜0.05), and compared with those of moderate patients, the levels of H-FABP, miRNA-21 and GDF15 increased in severe patients(P＜0.05). Modified early warning score(MEWS)≥ 7, HEART score ≥ 5, and the expression levels of H-FABP, miRNA-21, and GDF15 were higher in patients with decreased renal function(P＜0.05). ROC analysis showed that the sensitivity of H-FABP, miRNA-21 and GDF15 in the diagnosis of acute chest pain was lower than that of combinations of the three(0.692, 0.726, 0.785, 0.867, respectively). 
Conclusion H-FABP, miRNA-21, and GDF15 are highly expressed in the serum of patients with acute chest pain. Measuring the changes of H-FABP, miRNA-21, and GDF15 is of significance in predicting the condition of patients with acute chest pain.

Key words: chest pain, heart-type fatty acid-binding protein, microRNA-21, growth and differentiation factor-15