河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (11): 1285-1288.doi: 10.3969/j.issn.1007-3205.2023.11.008

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支气管肺炎患者NLR与T细胞免疫水平相关性

  

  1. 江苏省溧阳市人民医院呼吸与危重症学科，江苏 溧阳 213300

  • 出版日期:2023-11-25 发布日期:2023-12-05
  • 作者简介:周迎春（1987-），女，江苏溧阳人，江苏省溧阳市人民医院主治医师，医学学士，从事呼吸系统感染及肿瘤疾病诊治研究。
  • 基金资助:
    江苏省科技计划项目(2019GH241111)

Correlation between NLR and the level of T cell immunity in patients with bronchopneumonia

  1. Department of Respiratory and Critical Care, Liyang People′s Hospital, Jiangsu Province, Liyang 213300, China

  • Online:2023-11-25 Published:2023-12-05

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摘要： 目的 探讨支气管肺炎患者中性粒细胞/淋巴细胞比值（neutrophil/lymphocyte ratio，NLR）与T细胞免疫水平的相关性。
方法 选取支气管肺炎患者104例为研究组，支气管异物患者50例为对照组。根据临床检查结果将研究组患者分为轻症组（61例）和重症组（43例），检测所有患者NLR、细胞因子［干扰素γ（interferon-γ，INF-γ）、白细胞介素4（interleukin-4，IL-4）、INF-γ/IL-4］及T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）水平，分析NLR与支气管肺炎患者T细胞免疫水平的相关性。
结果 轻症组和重症组NLR、INF-γ、INF-γ/IL-4高于对照组，重症组NLR、INF-γ、INF-γ/IL-4高于轻症组（P＜0.05）。轻症组和重症组CD3+、CD4+、CD4+/CD8+低于对照组，CD8+高于对照组，重症组CD3+、CD4+、CD4+/CD8+低于轻症组，CD8+高于轻症组（P＜0.05）。支气管肺炎患者NLR与INF-γ、INF-γ/IL-4呈正相关（P＜0.05），与CD4+、CD4+/CD8+呈负相关（P＜0.05），与IL-4、CD3+、CD8+无相关性（P＞0.05）。
结论 支气管肺炎患者NLR与INF-γ、INF-γ/IL-4等细胞因子及CD3+、CD4+/CD8+等T淋巴细胞亚群存在相关性，NLR能在一定程度上反映支气管肺炎患者T细胞免疫水平。


关键词: 支气管肺炎, 中性粒细胞/淋巴细胞比值, T淋巴细胞

Abstract: Objective To investigate the correlation between neutrophil/lymphocyte ratio (NLR) and the level of T cell immunity in patients with bronchopneumonia. 
Methods A total of 104 patients with bronchopneumonia were selected as the research group and 50 patients with bronchial foreign body were selected as the control group. According to the clinical examination results, the patients in the research group were divided into mild group (n=61) and severe group (n=43). The levels of NLR, cytokines ［interferon-γ (INF-γ)］, interleukin-4 (IL-4), INF-γ/IL-4 and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) were detected in all patients. The correlation between NLR and the level of T cell immunity in patients with bronchopneumonia was analyzed.  
Results NLR, INF-γ and INF-γ/IL-4 in mild and severe groups were higher than those in control group, and higher in severe group than in mild group (P＜0.05). CD3+, CD4+ and CD4+/CD8+ in mild and severe groups were lower than those in control group, and CD8+ was higher than that in control group; CD3+, CD4+ and CD4+/CD8+ in severe group were lower than those in mild group, and CD8+ was higher than that in mild group (P＜0.05). NLR was positively correlated with INF-γ and INF-γ/IL-4 in patients with bronchopneumonia (P＜0.05), and negatively correlated with CD4+ and CD4+/CD8+ (P＜0.05), which, however, had no correlation with IL-4, CD3+ and CD8+ (P＞0.05). 
Conclusion NLR is correlated with INF-γ, INF-γ/IL-4 and T lymphocyte subsets such as CD3+ and CD4+/CD8+. NLR can reflect the level of T cell immunity in patients with bronchopneumonia to a certain extent.


Key words: bronchopneumonia, neutrophil/lymphocyte ratio, T-lymphocytes

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