关键词: 心肌再灌注损伤, 匹伐他汀, 氧化性应激

Abstract: Objective To explore the effects of pitavastain on the role of oxidative stress in a rat model of myocardial ischemia-reperfusion,which will provide a theoretical basis for pitavastain clinical application in myocardial ischemia-reperfusion.Methods A total of 42 male SD rats were randomly assigned to three groups:Sham group,control group (IR group)and experimental group(Statin group).In Sham group and control group,2 mL saline was irrigated into stomach daily for four weeks,0.42 mg/kg pitavastain dissolved in 2 mL saline was given in experimental group.In surgery,we wore line under the coronary artery without ligation in Sham group,and ligated the line for 30 minutes and then released it for 2 hours in IR group and Statin group.The levels of CK-MB were discerned after operation.Some myocardium tissue specimens under the line for ligation were used to detect the activity of total superoxide dismutase (T-SOD).The myocardial infarction size and risk area of each group were analyzed through comparing the differentiation of myocardium tissue stained by triphenyl tetrazolium chloride(TTC)and Evansblue by computer software system.Results The levels of CKMB elevated and TSOD contentdecreased significantly in control group and experimental group as compared with Sham group(P <0.01).In IR group,the level of CKMB was significantly higher than that of statin group,butlower when comes to TSOD content(P <0.01).There were no statistical significance betweenstatin group and IR group compared with area at risk(P > 0.05).Statin group significantlyreduced infarct size compared with IR group(P <0.01).Conclusion Pitavastatin could increaseantioxidant capacity and it took a positive role in ischemiareperfusion myocardial injuryprevention.

Key words: myocardial reperfusion injury, pitavastain, oxidative stress