关键词: 糖尿病, 2 型, 胰岛素, 普通, 人, 天冬胰岛素

Abstract: Objective To compare the safety and efficacy of biphasic insulin aspart 50 (BIAsp 50 )and premixed human insulin 50 (BHI 50 )on type 2 diabetes mellitus (T2DM) patients.Methods A total of 76 T2DM patients were randomly divided into BIAsp 50 group(38 cases)and BHI 50 group(38 cases).The fasting blood glucose (FBG),2-hour postprandial blood glucose (2hPG)and glycated hemoglobin(HbA1 c)after 12 weeks′insulin aspart 50 treatment, the insulin dosage and hypoglycemic episodes were compared.Results After 12 weeks′treatment,the decrease of 2hPG in BIAsp 50 group was more than that in BHI 50 group (P <0.05).Besides,in BIAsp 50 group,the incidence of hypoglycemic episodes was reduced,the insulin dosage was smaller,both showing significant differences (P <0.05).Conclusion BIAsp 50 could improve treatment efficiency and patients′ compliance.It is economic and suitable for widely clinical application.

Key words: diabetes mellitus, type 2, insulin, regular, human, insulin aspart