关键词: 依托咪酯, 二异丙酚, 麻醉, 全身, 血流动力学

Abstract: Objective To observe the hemodynamic changes of anesthesia inducement of etomidate combined with propofol in elderly patients during general anesthesia. Methods Total 100 elderly patients with general anesthesia were randomly divided into five groups of propofol( group P ), etomidate( group E ),propofol combined with etomidate 1( group PE1 ),2( group PE2 )and 3( group PE3 )according inducement agents. The systolic blood pressure( SBP),diastolic blood pressure( DBP), mean arterial pressure( MAP),heart rate( HR)and bispectral index( BIS)value were recorded before inducement of anesthesia( T0 ),before laryngoscope insertion( T1 ),instant( T2 ),1min( T3 ),3min (T4),5min(T5)and 10(T6)min after intubation in each groups. Results Compared with T0,SBP, DBP,MAP and HR at T1 were significantly reduced in five groups(P<0. 05);SBP,DBP and MAP were significantly reduced in group P and PE2(P<0. 05),and DBP,MAP,HR in group PE1 were not different from that of at T2(P>0. 05);SBP,DBP and MAP in group P,E and PE1 were not different from that of at T3(P>0. 05),HR in group E and group PE3 were significantly elevated(P <0. 05). SBP,DBP and MAP at T1 -T3 and HR at T3 in group E were significantly higher than that in group P( P <0. 05 );SBP,DBP and MAP in group PE1 at T1 -T4 were higher than that in group P(P<0. 05),and HR at T3 in group PE1 was lower than that in group E(P<0. 05);At all the time point,SBP,DBP,MAP and HR in group PE2 were not different from those in group P(P>0. 05);SBP,DBP,MAP and HR in group PE3 at T1 -T6 were higher than those in group P(P<0. 05). BIS values in five groups decreased significantly after inducement( P <0. 05 ),and there were no significant changes between groups( P >0. 05 ). Conclusion Administration of propofol 0 . 8 mg/kg combined with etomidate 0 . 15 mg/kg can achieve more stable hemodynamic changes than administration of the two agents individually.

Key words: etomidate, propofol, anesthesia, general, hemodynamics