河北医科大学学报

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复治脊柱结核的治疗方案及疗效的临床研究

  

  1. 1.河北省胸科医院骨科,河北 石家庄 050041;2.河北省人民医院急诊科,河北 石家庄 050051
  • 出版日期:2016-05-25 发布日期:2016-05-20
  • 作者简介:姚黎明( 1980- ),男,河北石家庄人,河北省胸科医 院主治医师,医学硕士,从事骨科疾病诊治研究。
  • 基金资助:
    河北省科学技术研究与发展计划( 1120140287 )

Clinical study on the therapeutic scheme and curative effect of retreating postoperative spinal tuberculosis

  1. 1.Department of  Orthopedics, the Chest Hospital of Hebei Province, Shijiazhuang 050041, China;
    2.Department of  Emergency, the General Hospital of Hebei Province, Shijiazhuang 050051, China
  • Online:2016-05-25 Published:2016-05-20

摘要: [摘要] 目的 探讨复治脊柱结核的手术治疗方案及疗效。方法 回顾性分析收治的针对不同原因采用个体
化治疗的 35 例复治脊柱结核患者的相关临床资料。再次手术方式:单纯病灶清除、窦道切除术 10 例,病灶清除植
骨融合术 5 例,病灶清除植骨融合内固定 8 例,病灶清除植骨融合原内固定物取出 7 例,病灶清除植骨融合原内固
定物取出再次内固定 5 例。术后联合应用抗结核药物治疗 18~24 个月,随访观察病灶治愈、植骨融合情况并分别
应用视觉模拟量表( VisualAnalogueScale , VAS )评分评估疼痛症状及 Oswestry 功能障碍指数评分评估脊柱功能
改善情况。结果 随访时间 28~48 个月。所有患者均达临床治愈且术后植骨顺利愈合。随访期内未见复发病例。
VAS 评分由入院后第 1 天( 6. 41±2.56 )分降至术后第 7 天( 3. 20±1. 48 )分( P <0.05 );患者终末随访时 Oswestry
功能障碍指数评分(
15. 42±7.56 )分较术前( 65. 34±25.48 )分明显降低( P <0.01 )。结论 多种因素综合作用影响
脊柱结核术后复治的疗效。全面系统地评估术前状态、参考既往治疗方案制定个体化的药物及手术应对策略,可
显著减轻疼痛并改善功能,是提高脊柱结核的复治疗效的关键。

关键词: 结核, 脊柱, 药物疗法, 外科手术

Abstract: [
Abstract ] Objective Toinvestigatethetherapeuticschemeandcurativeeffectofretreating
postoperativespinaltuberculosis.Methods Atotalof35patientswithpostoperativerecurrence
ofspinaltuberculosis underwentindividualtreatment , which werestudied retrospectively.
Individualoperation wasperformed : 10cases withdebridementandsinusresection , 5 with
debridementandinterbodyfusion , 8 withdebridement , interbodyfusionandanteriorinernal
fixation , 7withdebridement , interbodyfusionanddislodgmentofinternalfixator , 5withone
stagedebridement , interbodyfusion , dislodgmentofprimaryinternalfixator , combinedanterior
or posterior internal fixation. All patients were followed regularly , and treated by
antituberculosischemotherapyfor18~24months.Clinicaleffect , focusheelingandbonefusion
wereevaluatedatfollow-upperiod.Theoutcomeswereretrospectivelyanalysedbypreoperative
andpostoperativeVisualAnalogueScale ( VAS ) scoresand Oswestry DisabilityIndex ( ODI )
scores.Results Thefollow-upperiod wererangedfrom 28to48 months.Allcases were recovered , andtherehadnorecurrence.Allhadgoodhealingofbonegraftafteroperation.After
admissiontheVASscoreswasdecreasedfrom6. 41±2.56offirstdayafteradmissionto3. 20±
1.48ataweekafteroperation ( P <0.05 ) .ThereweresignificentimprovementsofODIscores
from65. 34±25.48preoperativelyto15. 42±7.56atthefinalfollow-up ( P <0.01 ) .Conclusion
Thecurativeeffectofretreatingpostoperativespinaltuberculosiswasmultifactoriallyeffectedby
manycomplicatedfactors.Theadequatepreoperativeevaluation , individualantituberculosis
chemotherapyandoperationaccordingtoprevioustherapeuticschemecouldimprovethepain.
Thefunctionalongwithqualityoflifewerekeytoimprovingthecurativeeffect.

Key words:  tuberculosis, spinal , drugtherapy , surgicalprocedures, operative