河北医科大学学报

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含鱼油脂肪乳肠外营养对危重症患者影响的Meta分析

  

  1. 河北医科大学第一医院营养科,河北 石家庄 050031
  • 出版日期:2016-08-25 发布日期:2016-09-01
  • 作者简介:胡环宇( 1985- ),女,河北冀州人,河北医科大学第 一医院技师,医学学士,从事临床营养学研究。
  • 基金资助:
    中国营养学会帝斯曼基金资助课题( DSM201317 );河北省医学科学研究重点课题( ZD20140186 )

Effect of parenteral nutrition containing fish oil fat emulsion in critically ill patients:a Metaanalysis

  1. Department of Nutrition, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China
  • Online:2016-08-25 Published:2016-09-01

摘要: [摘要] 目的 系统评价含鱼油脂肪乳的肠外营养对成年危重症患者的影响。方法 计算机检索万方、 CNKI 、
TheCochraneLibrary ( CochraneCentralRegisterofControlledTrials )、 pubmed 数据库。按照纳入标准对研究进
行资料提取、利用改良 Jadad 评分进行方法学质量评价,采用 RevMan5.1 软件进行 Meta 分析。结果 共纳入 28 个
随机对照实验(
randomizedcontrolledtrail , RCT ),共计 1444 例患者,其中含 9 个高质量研究。 Meta 分析结果显
示,鱼油组急性生理与慢性健康 Ⅱ ( acutephysiologyandchronicheathevaluation Ⅱ , APACHEⅡ )评分[ SMD=
-0. 55 , 95% CI ( -0. 76 , -0. 34 ), P <0.00001 , I
2 =44% ]、
ICU 停留时间[ SMD=-1. 06 , 95% CI ( -1. 43 , -0. 70 ),
P <0.00001 , I
2 =84% ]、感染性并发症[
OR =0.42 , 95% CI ( 0.28 , 0.65 ), P <0.0001 ; I
2 =0% ]与对照组差异均
有统计学意义。但 2 组 28d 病死率[ OR =0.59 , 95% CI ( 0.32 , 1.10 ), P =0.10 , I
2 =0% ]差异无统计学意义。结
论 鱼油脂肪乳肠外营养可部分改善成年危重症患者的临床疗效,但并未对患者近期预后产生影响

关键词: 胃肠外营养, 鱼油, Meta分析

Abstract: [
Abstract ] Objective Toevaluatetheeffectofparenteralnutritioncontainingfishoilfat
emulsiononadultcriticallyillpatients.Methods Studieswereidentifiedby Wanfang , CNKI ,
TheCochraneLibrary ( CochraneCentralRegisterofControlled Trials ), pubmedsearchfor
originalarticles.AccordingtotheinclusioncriteriaandJadad , dataoftheincludedstudieswere
extracted , andthe methodologicalquality wasevaluated.Then Meta-analysiswasperformed
usingRevMan5.1.Results Atotalof28RCTsinvolving1444patientsincluding9highquality
trials wereincluded.Meta-analysis showed that compared with controlled group , Acute
PhysiologyandChronicHealthEvaluation ( APACHE ) Ⅱscore [ SMD=-0. 55 , 95% CI ( -0. 76 ,
-0. 34 ), P <0.00001 , I
2 =14% ], LengthofICU stay [
SMD= -1. 06 , 95% CI ( -1. 43 ,
-0. 70 ), P <0.00001 , I
2 =84% ] andinfectiouscomplications [
OR =0.42 , 95% CI ( 0.28 ,
0.65 ), P <0.0001 , I
2 =0% ]
hadsignificantdifferences.Buttherewerenosignificantdifference
in28-d mortality [ OR =0.59 , 95% CI ( 0.32 , 1.10 ), P =0.10 , I
2 =0% ]
.Conclusion The
parenteralnutritioncontainingfishoilfatemulsioncanpartlyimprovetheconditionsofcritically llpatients , butdidnotaffecttherecentprognosis.

Key words: parenteralnutrition , fishoils , Meta-analysis