rhuEPO辅助治疗对新生儿缺氧缺血性脑病氧化应激损伤及Caspase3、ACT A水平的影响

doi:10.3969/j.issn.10073205.2017.11.013

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨重组人促红细胞生成素（recombinant human erythropoietin,rhuEPO）辅助治疗对新生儿缺氧缺血性脑病（hypoxicischemic encephalopath，HIE）氧化应激损伤及半胱氨酸天冬氨酸蛋白酶3（cysteine aspartic protease3，Caspase3）、内源性激活素A(endogenous activin A,ACT A)的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将130例HIE患者随机分为A组（rhuEPO辅助常规治疗）与B组（常规治疗）各65例，并选择65例同期健康新生儿纳入C组，比较A组与B组在治疗效果、不良反应率差异及3组在治疗当天、治疗1周、治疗4周时超氧化物歧化酶（superoxide dismutase,SOD）、丙二醛（malondialdehyde,MDA）、Caspase3、ACT A、新生儿神经行为测定（neonatal behavioral neurological assessment,NBNA）的差异。
〖HTH〗结果〖HTSS〗〖KG*2〗A组疗效（92.3%）高于B组（70.7%），差异有统计学意义（P＜005）。不同时间点C组SOD、MDA、Caspase3、ACT A水平无显著变化，而A、B组SOD水平显著增高，3组在组间、时点间以及组间·时点间交互作用差异均有统计学意义（P＜005）；A、B组ACT A水平逐渐增高，且B组高于A、C组，3组在组间、时点间以及组间·时点间交互作用差异均有统计学意义（P＜005）；A、B组Caspase3呈先升高后降低的趋势，3组在组间、时点间以及组间·时点间交互作用差异均有统计学意义（P＜005）；A、B组MDA水平逐渐下降，3组在组间、时点间以及组间·时点间交互作用差异均有统计学意义（P＜005）；A、B组NBNA评分逐渐升高，3组在组间、时点间以及组间·时点间交互作用差异均有统计学意义（P＜005)。A组不良反应发生率（7.7%）低于B组（30.8%），差异有统计学意义（P＜005)。
〖HTH〗结论〖HTSS〗〖KG*2〗Capspase3及ACT A均参与HIE病理生理过程，且通过rhuEPO辅助治疗HIE，有利于降低该病氧化应激损伤及Caspase3、ACT A水平。

关键词: 缺氧缺血, 脑, 重组人促红细胞生成素, 婴儿, 新生

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the effects of rhuEPO on hypoxicischemic encephalopath(HIE） oxidative stress injury and Caspase3， endogenous activin A（ACT A).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and thirty patients with HIE were randomly assigned to group A(rhuEPO adjuvant therapy) and group B(conventional therapy), 65 patients in each group. And 65 cases of healthy newborns were choosen into the group C in order to compare the treatment effect, adverse rate of difference and the differences of superoxide dismutase(SOD), malondialdehyde(MDA), Caspase3, ACT A and neonatal behavioral neurological assessment(NBNA) observed on the day of treatment, 1 week of treatment and 4 weeks of treatment between group A and B.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Group A efficiency(92.3%) was higher than group B(70.7%), the difference was statistically significant(P＜005); The levels of SOD, MDA, Caspase3 and ACT A in group C were not significantly changed in the different time points, while the levels of SOD in group A and group B were significantly higher, there was significant difference in the intergroup, interpoint, and intergroup/hourtime interactions among the three groups(P＜005). The levels of ACT A in group A and B were increased gradually, there was significant difference in the intergroup, interpoint, and intergroup/hourtime interactions between the three groups(P＜005). The levels of Caspase3 in group A and B were increased first and then decreased, there was significant difference in the intergroup, interpoint, and intergroup/hourtime interactions between the three groups(P＜005). The level of MDA in group A and B were decreased gradually, in the intergroup, interpoint, and intergroup/hourtime interactions between the three groups(P＜005). The NBNA scores of group A and B were gradually increased, there was significant difference in the intergroup, interpoint, and intergroup/hourtime interactions between the three groups(P＜005). The incidence of adverse reactions in A group(7.7%) were lower than the B group(30.8%), the difference was statistically significant.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Capspase3 and ACT A are involved in the pathophysiological process of HIE, and rhuEPO is used to treat HIE, which is beneficial to reduce the oxidative stress injury and levels of Caspase3 and ACT A.

Key words: hypoxiaischemia, brain, recombinant human erythropoietin, infant, newborn

石境懿，夏〓利，张〓衡，朱书瑶. rhuEPO辅助治疗对新生儿缺氧缺血性脑病氧化应激损伤及Caspase3、ACT A水平的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.11.013.

SHI Jingyi, XIA Li, ZHANG Heng, ZHU Shuyao. Effects of rhuEPO adjuvant therapy on oxidative stress injury and Caspase3 and ACT A levels in neonates with hypoxicischemic encepha lopathy#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.11.013.

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rhuEPO辅助治疗对新生儿缺氧缺血性脑病氧化应激损伤及Caspase3、ACT A水平的影响

Effects of rhuEPO adjuvant therapy on oxidative stress injury and Caspase3 and ACT A levels in neonates with hypoxicischemic encepha lopathy#br#

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