河北医科大学学报

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Kiss1、Kiss-1R蛋白在胃腺癌中的表达及临床意义#br#

  

  1. 1.河北省承德市中心医院消化内科，河北 承德 067000;2.河北医科大学第一医院医联体办公室，
    河北 石家庄 050031; 3.河北医科大学第一医院内镜中心，河北 石家庄 050031
  • 出版日期:2018-05-25 发布日期:2018-05-16
  • 作者简介:姜海斌（1981-），男，河北承德人，河北省承德市中心医院主治医师，医学硕士，从事消化内科疾病诊治研究。
  • 基金资助:
    河北省科技计划项目（14277752D）；河北省医学科学研究重点课题（20160298）；河北省重点研发计划项目（18277741D）

Expression of Kiss1 and Kiss1R protein in gastric adenocarcinoma and its clinical significance#br#

  1. 1.Department of Gastroenterology, the Central Hospital of Chengde, Hebei Province， Chengde
    067000, China； 2.Department of Medical Union Office,  the First Hospital of Hebei Medical
    University, Shijiazhuang 050031, China； 3.Department of Endoscopy Center, the First
    Hospital of Hebei Medical University, Shijiazhuang 050031, China
  • Online:2018-05-25 Published:2018-05-16

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨亲吻素（kisspeptin 1，Kiss1）、亲吻素受体（kisspeptin 1 receptor，Kiss1R）2种蛋白在胃腺癌浸润、转移过程中的作用及其临床意义。
〖HTH〗方法〖HTSS〗〖KG*2〗收集胃腺癌组织40例，癌旁胃正常黏膜组织28例，采用免疫组织化学SP方法检测Kiss1、Kiss1R 2种蛋白在2组中的表达情况，分析其与临床病理特征之间的关系。
〖HTH〗结果〖HTSS〗〖KG*2〗Kiss1及Kiss1R 蛋白在胃腺癌组织的阳性表达率均显著低于癌旁胃正常黏膜组织（P＜001）；低分化、有淋巴结转移、TNM Ⅲ+Ⅳ期胃腺癌组织Kiss1蛋白阳性表达率低于中高分化、无淋巴结转移、Ⅰ+Ⅱ期胃腺癌组织，差异有统计学意义（P＜005）；不同性别、年龄、肿瘤大小和肿瘤浸润深度胃腺癌组织Kiss1蛋白阳性表达率差异无统计学意义（P＞005）。不同性别、年龄、肿瘤大小、分化程度、浸润深度、淋巴结转移、TNM分期胃腺癌组织中Kiss1R蛋白阳性表达率差异无统计学意义（P＞005）。Kiss1与Kiss1R蛋白在胃腺癌组织中表达呈正相关（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗Kiss1在胃腺癌进展过程中发挥抑制肿瘤转移的作用，其有潜力成为判断胃腺癌转移和预后的生物学指标； Kiss1/Kiss1R信号通路有望成为胃腺癌治疗的有效干预靶点。

关键词: 胃肿瘤, 亲吻素, 免疫组织化学

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the role of kisspeptin 1(Kiss1) and kisspeptin 1 receptor(Kiss1R) in the invasion and metastasis of gastric adenocarcinoma and its clinical significance.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 40 cases of gastric adenocarcinoma tissues and 28 cases of normal gastric mucosa were collected. Immunohistochemical SP method was used to detect the expression of Kiss1 and Kiss1R in two groups. The relationship between them and clinical pathological features was analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The expression of Kiss1 and Kiss1R protein in gastric adenocarcinoma group were significantly lower than that in normal gastric mucosa group(P＜001). The positive rate of Kiss1 protein expression in gastric adenocarcinoma tissues with Lowdifferentiation, lymph node metastasis and TNM Ⅲ+Ⅳ was lower than that of moderately welldifferentiated, no lymph node metastasis, and Ⅰ+Ⅱ(P＜005). The positive rate of Kiss1 protein expression was no significant difference in different sex, age, tumor size and depth of tumor invasion of gastric adenocarcinoma tissue(P＞005). There was no significant difference in the positive expression rate of Kiss1R protein in gastric adenocarcinoma between sex, age, gastric adenocarcinoma tumor size, differentiation degree, depth of invasion, lymph node metastasis and TNM staging(P＞005). The expressions of Kiss1 and Kiss1R protein in gastric adenocarcinoma were positively correlated(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Kiss1 can inhibit tumor metastasis during the progression of gastric adenocarcinoma, and it has the potential to be a biological indicator for judging the metastasis and prognosis of gastric adenocarcinoma. Kiss1/Kiss1R signaling pathway is expected to be an effective intervention target for the treatment of gastric adenocarcinoma.

Key words: stomach neoplasms, kisspeptins, immunohistochemistry

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