河北医科大学学报

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HBV X区基因突变与原发性肝癌预后的关系#br#

  

  1. 1.河北医科大学第四医院消化内科，河北 石家庄 050011；2.河北医科大学第四医院实验动物中心，河北 石家庄 050011
  • 出版日期:2018-05-25 发布日期:2018-05-16
  • 作者简介:吴忱思(1982-)，女，河北石家庄人，河北医科大学第四医院主治医师，医学硕士，从事消化内科疾病诊治研究。
  • 基金资助:
    河北省科技计划项目(152777148)

The relationship between the mutations in hepatitis B virus X protein gene and the postoperative survival in hepatocellular carcinoma#br#

  1. 1.Department of Gastroenterology, the Fourth Hospital of Hebei Medical University,
    Shijiazhuang 050011, China; 2.The Center of Laboratory Animal, The Fourth Hospital of
    Hebei Medical University,  Shijiazhuang 050011, China
  • Online:2018-05-25 Published:2018-05-16

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨乙型肝炎病毒（hepatitis B virus，HBV）X区基因突变位点与原发性肝癌预后的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗对HBV X区基因进行PCR扩增及测序，鉴定其突变位点，应用KaplanMeier、Logrank test和Cox回归模型分析乙肝病毒相关性肝细胞肝癌（hepatitis B virus associated hepatocellular carcinoma,HBVHCC）患者的临床特征、突变位点与总生存期之间的关系。
〖HTH〗结果〖HTSS〗〖KG*2〗7个突变位点（1329、1341、1383、1461、1485、1544、1613）与HBVHCC患者的生存差异有统计学意义，4个突变位点（1317、1674、1753、1762/1764）具有临界统计学差异，肿瘤大小、门脉瘤栓以及5个突变位点（1329、1341、1383、1461、1485）与HBVHCC患者术后预后密切相关。
〖HTH〗结论〖HTSS〗〖KG*2〗肿瘤大小、门脉瘤栓以及5个突变位点（1329、1341、1383、1461、1485）被确定为与HBVHCC患者术后预后相关的独立危险因素。

关键词: 肝肿瘤, 乙型肝炎病毒, 预后

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the relationship between the mutations in hepatitis B virus X gene and the postoperative survival in hepatocellular carcinoma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The HBV X gene was amplified and sequenced, and the HBV mutations were identified. The relationship between virological factors and HBVHCC survival was analyzed with the KaplanMeier method, the Logrank test and the Cox proportional hazards model.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The following seven sites were associated with postoperative survival at statistically significant levels in HCC tissue: 1329， 1341， 1383， 1461， 1485， 1544， 1613. The following four mutational sites were identified for their association with survival at a borderline significance level: 1317， 1674， 1753， 1762/1764. The tumor size， portal vein thrombosis and the following five mutational sites were associated with postoperative survival in HCC patients: 1329， 1341， 1383， 1461, 1485. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The tumor size，portal vein thrombosis and the following five mutational sites were identified as independent predictors of postoperative survival in HCC patients: 1329， 1341， 1383， 1461， 1485.

Key words: liver neoplasms； hepatitis B virus； , prognosis

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