河北医科大学学报

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乙酰半胱氨酸泡腾片预防非小细胞肺癌放射性肺炎的临床价值分析

  

  1. 河北北方学院附属第一医院放疗科，河北 张家口 075000
  • 出版日期:2018-09-25 发布日期:2018-08-28
  • 作者简介:卢秀荣（1980-），女，河北沽源人，河北北方学院附属第一医院主治医师，医学硕士，从事恶性肿瘤放射治疗研究。
  • 基金资助:
    张家口市科学技术研究与发展计划（1421151D）

Clinical analysis of acetylcysteine effervescent tablets for radiation pneumonitis prevention in nonsmall cell lung cancer#br#

  1. Department of Radiation Oncology, the First Hospital Affiliated with Northern Hebei University, Zhangjiakou 075000, China
  • Online:2018-09-25 Published:2018-08-28

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨乙酰半胱氨酸泡腾片预防非小细胞肺癌放射性肺炎的临床价值。
〖HTH〗方法〖HTSS〗〖KG*2〗将非小细胞肺癌患者68例根据入院先后随机分为2组各34例，应用调强放疗的患者为对照组，在放疗的同时口服乙酰半胱氨酸泡腾片的患者为观察组。观察2组治疗前后肺功能第1秒用力呼气容积（forced  expiratory volume in first second，FEV1）、用力肺活量(forced vital capacity,FVC)，血清指标白细胞介素6(interleukin6,IL6)、肿瘤坏死因子α（tumor necrosis factorα,TNFα），治疗后放射性肺炎发生率和骨髓抑制情况。
〖HTH〗结果〖HTSS〗〖KG*2〗对照组治疗后FEV1和FVC水平明显低于治疗前（P＜005），观察组治疗后与治疗前变化不大， 观察组治疗后FEV1和FVC水平高于对照组，差异有统计学意义（P＜005）；治疗后2组IL6和TNFα水平均较治疗前升高，但观察组升高幅度小，治疗后观察组IL6和 TNFα水平明显低于对照组，差异有统计学意义（P＜005）。观察组3~5级放射性肺炎发生率为14.7%，明显低于对照组的35.3%（P＜005）；骨髓抑制发生率为50.0%，明显低于对照组的79.4%（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗非小细胞肺癌患者应用乙酰半胱氨酸泡腾片可缓解炎症反应，改善肺通气功能，减少放射性肺炎和骨髓抑制，值得在临床上推广应用。

关键词: 癌, 非小细胞肺, 辐射性肺炎, 乙酰半胱氨酸

Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the clinical values of acetylcysteine effervescent tablets in prevention of radiation pneumonitis for patients with nonsmall cell lung cancer(NSCLC).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 68 consecutives as NSCLC were enrolled and divided randomly into control and observation groups, each with 34 cases, Control group was received intensitymodulated radiation, observation group was adopted oral acetylcysteine effervescent tablets. The differences of lung function forced expiratory volume in first second (FEV1), forced vital capacity(FVC), serum interleukin6(IL6), tumor necrosis factorα(TNFα) levels and the rates of radiation pneumonia and bone marrow suppression were compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The values of FEV1 and FVC in control group after treatment were lower than before treatment(P＜005),while there were no statistical difference in observation group(P＞005). The values of FEV1 and FVC in observation 〖JP2〗group were significantly higher than in control group after treatmen(P＜005). The levels of IL6〖JP〗 and TNFα in the two groups were higher than that before treatment(P＜005), but observation group were still significantly lower than control group after treatmen(P＜005).The incidences of 3~5 level radioactive pneumonia and bone marrow suppression in observation group were both significantly less than that in control group(14.7% vs 35.3%, 50.0% vs 79.4%, P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓It can greatly alleviate inflammation,improve pulmonary ventilation function,reduce the radioactive pneumonia and bone marrow suppression rates in patients with NSCLC by acetylcysteine effervescent tablets.

Key words: carcinoma, nonsmallcell lung； radiation pneumonitis, acetylcysteine

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