河北医科大学学报

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大面积脑梗死患者颅内压与血清NSE、S-100B蛋白变化的关系

  

  1. 华北理工大学附属医院神经内科，河北 唐山 063000
  • 出版日期:2019-02-25 发布日期:2019-01-16
  • 作者简介:屈征（1994-），男，河北廊坊人，华北理工大学附属医院医学硕士研究生，从事神经内科疾病诊治研究。
  • 基金资助:
    河北省医学科学研究重点课题（ZL20140279）

Relationship between intracranial pressure and the changes of serum NSE and S100B protein in patients with massive cerebral infarction#br#

  1. Department  of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei Province, Tangshan 063000, China
  • Online:2019-02-25 Published:2019-01-16

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗分析大面积急性脑梗死患者颅内压变化与血清神经元特异性烯醇化酶（neuronspecific enolase,NSE）、S100B蛋白变化的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗选择符合标准的30例大面积脑梗死患者，应用无创颅内压监测仪监测颅内压，对符合标准患者进行入院后24 h内以及发病后第3天、第5天、第7天颅内压的动态监测，应用酶联免疫吸附测定法监测同时期患者血清NSE、S100B蛋白水平，并与30例健康人(对照组)比较，对大面积脑梗死患者急性期颅内压变化与血清NSE、S100B蛋白含量变化进行相关性分析。
〖HTH〗结果〖HTSS〗〖KG*2〗发病24 h内病例组颅内压、血清NSE和S100B蛋白水平均高于对照组，差异有统计学意义(P＜005)；病例组入院第3天、第5天、第7天颅内压、血清NSE和S100B蛋白水平均高于入院24 h,在入院第7天开始下降，但仍高于入院24 h，差异均有统计学意义(P＜005)。
〖HTH〗结论〖HTSS〗〖KG*2〗大面积脑梗死患者颅内压变化伴随着血清NSE和S100B蛋白水平变化，可通过测定血清NSE、S100B蛋白含量变化间接反映颅内压变化，对临床评估病情严重程度及预后有一定参考价值。

关键词: 脑梗死, 颅内压, 神经元特异烯醇化醇, S-100B蛋白

Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze the relationship between the changes of intracranial pressure in patients with massive acute cerebral infarction and the changes of serum neuron specific enolase neuronspecific enolase（NSE） and S100B protein.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty patients with large area cerebral infarction who met the criteria were selected, and noninvasive intracranial pressure monitor was used to monitor intracranial pressure. Dynamic monitoring of intracranial pressure was performed on patients who met the criteria within 24 h after admission, 3 days after onset, 5 days after onset, and 7 days after onset. The application of enzyme linked immunosorbent assay in monitoring the protein level of S100B protein and serum NSE, and compared with 30 healthy people(control group), the serum level of NSE and S100B protein subtype and the intracranial pressure were made for the content correlation analysis.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The intracranial pressure, specific enolase and serum S100B protein in the case group were significantly higher than those in the control group within 24 h after onset. The difference was statistically significant(P＜005). In the case group,after the onset of 3 d, 5 d, 7 d of the intracranial pressure, the specific enolase and serum S100B protein were higher than the admission of 24 h, and began to decline on the 7 days after admission, but still higher than admission for 24 h.The difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The changes of intracranial pressure in patients with massive cerebral infarction accompanied by changes in serum NSE and S100B protein levels can reflect the changes of intracranial pressure indirectly by measuring the changes of serum NSE and S100B protein levels，expecting to become a certain reference value for clinical evaluation of the severity and prognosis of the disease.

Key words: brain infarction, intracranial pressure, 2phosphoDglycerate hydrolase, S100B protein

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