左乙拉西坦对全面性癫痫发作脑电图间期放电量变化和疗效的研究

doi:10.3969/j.issn.10073205.2019.02.003

河北医科大学学报

左乙拉西坦对全面性癫痫发作脑电图间期放电量变化和疗效的研究

河北医科大学附属河北省儿童医院神经内科，河北石家庄 050031

出版日期:2019-02-25 发布日期:2019-01-16
作者简介:杜雅坤（1979-），女，山东平邑人，河北医科大学附属河北省儿童医院主治医师，医学硕士，从事小儿神经内科疾病诊治研究。
基金资助:
河北省医学科学研究重点课题（20170397）

Study on changes of electroencephalogram interphase discharge and the clinical efficacy of levetiracetam in generalized seizures

Department of Neurology, Affiliated Hebei Children′s Hospital of Hebei Medical University, Shijiazhuang 050031， China

Online:2019-02-25 Published:2019-01-16

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗对比丙戊酸钠（sodiumvalproate,VPA）、左乙拉西坦（levetiracetam,LEV）单药治疗全面性癫痫发作脑电图间期放电数量的改变及临床效果。
〖HTH〗方法〖HTSS〗〖KG*2〗选择多种全面性癫痫发作患儿140例，随机分为对照组和观察组各70例，对照组采用VPA治疗，观察组采用LEV治疗，比较2组用药前后脑电图癫痫样放电变化、发作控制情况和安全性。
〖HTH〗结果〖HTSS〗〖KG*2〗治疗后观察组脑电图变化情况优于对照组，癫痫样放电消失或减少50%以上比例高于对照组，差异均有统计学意义(P＜005)。观察组临床疗效优于对照组，差异有统计学意义（P＜005），2组总有效率差异无统计学意义（P＞005）。2组不良反应发生率差异无统计学意义(P＞005)。
〖HTH〗结论〖HTSS〗〖KG*2〗LEV治疗各型全面性癫痫发作患儿均有效，在改善癫痫样放电方面疗效显著，不良反应发生率低，安全性良好。

关键词: 癫痫, 左乙拉西坦, 丙戊酸钠, 脑电图

Abstract: ［Abstract］〓Objective〖HTSS〗〓To compare the effects of the sodium valproate(VPA) and levetiracetam(LEV) monotherapy on the changes of electroencephalogram(EEG) interphase discharge quantity and the clinical effect in generalized seizures.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 140 cases of various generalized epilepsy children were selected andrandomly and were divided into control group and observation group, 70 cases in each group. Control group was treated with sodium valproate. The observation group was treated with levetiracetam. The changes of EEG epileptiform discharge, seizure control and safety before and after treatment were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After treatment, the change of EEG in the observation group was better than that in the control group, and the proportion of interictal epileptiform activity(IEA) disappearing or decreasing by more than 50% was higher than that in the control group（P＜005).The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant（P＜005), while the total effective rate of the two groups was not statistically significant（P＞005).There was no statistically significant difference in the incidence of adverse reactions between the two groups（P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓LEV is effective in the treatment of all types of children with generalized epileptic seizures. It has significant effect in improving IEA, low incidence of adverse reactions and good safety.

Key words: epilepsy； levetiracetam, sodiumvalproate, electroencephalogram

杜雅坤，冯宗怀，王丽辉，张〓静，张晓青，郑华城*. 左乙拉西坦对全面性癫痫发作脑电图间期放电量变化和疗效的研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.02.003.

DU Yakun, FENG Zonghuai, WANG Lihui, ZAHNG Jing， ZHANG Xiaoqing, ZHENG Huacheng*. Study on changes of electroencephalogram interphase discharge and the clinical efficacy of levetiracetam in generalized seizures[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.02.003.

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左乙拉西坦对全面性癫痫发作脑电图间期放电量变化和疗效的研究

Study on changes of electroencephalogram interphase discharge and the clinical efficacy of levetiracetam in generalized seizures

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