小切口劈核术联合rhEGF滴眼液治疗白内障患者的效果及对BUT、SⅠt的影响

doi:10.3969/j.issn.10073205.2019.06.015

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察小切口劈核术联合重组人表皮生长因子（recombinant human epidermal growth factor,rhEGF）滴眼液治疗白内障患者的效果及对泪膜破裂时间（breakup time,BUT）和泪液分泌试验（schlrmer Ⅰ test,SⅠt）的影响。
〖HTH〗方法〖HTSS〗〖KG*2〗将行小切口劈核术的核性白内障患者150例（160眼）按随机数字表法分为观察组和对照组各75例（80眼）。2组均采用小切口劈核术，术后对照组应用妥布霉素地塞米松滴眼液和双氯芬酸钠滴眼液，观察组在对照组基础上应用rhEGF滴眼液。于治疗前（T0）、术后1周（T1）、术后4周（T2）、术后8周（T3）、术后12周（T4）比较2组视力、散光程度、BUT、SⅠt。比较2组术后4周不良反应发生情况。
〖HTH〗结果〖HTSS〗〖KG*2〗2组术后视力均呈逐渐升高趋势，观察组视力高于对照组，其组间、时点间、组间·时点间交互作用差异均有统计学意义（P＜005）。2组术后散光度均呈逐渐降低趋势，其时点间差异有统计学意义（P＜005），而组间、组间·时点间交互作用差异均无统计学意义（P＞005）。2组术后BUT和SⅠt均呈先降低后升高趋势，观察组BUT和SⅠt高于对照组，其组间、时点间、组间·时点间交互作用差异均有统计学意义（P＜005）。观察组角膜水肿、干眼症及总不良反应发生率明显低于对照组（P＜005）。
〖HTH〗结论〖HTSS〗〖KG*2〗采用小切口劈核术联合rhEGF滴眼液治疗核性白内障效果良好，能够明显缩短患者术后视力恢复时间，促进患者术后泪液分泌，有助于减少术后并发症的发生，值得在临床中推广应用。

关键词: 白内障, 小切口劈核术, 表皮生长因子

Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the effect of small incision nucleus fragmentation method combined with rhEGF eye drops on cataract patients and the effects of breakup time(BUT) and schlrmer Ⅰ test(SⅠt).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and fifty patients(160 eyes) who underwent small incision nucleus surgery were enrolled in this study. The patients were divided into observation groups according to the random number table method. And the control group, each group of 75 cases(80 eyes). Vision, astigmatism, BUT, SⅠt were compared between two groups before treatment(T0), 1 week after surgery(T1), 4 weeks after surgery(T2), 8 weeks after surgery(T3), and 12 weeks after surgery(T4). The incidence of adverse reactions was compared between two groups at 4 weeks after operation.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The visual acuity of the two groups was gradually increased, and the visual acuity of the observation group was higher than that of the control group, there was significant difference between groups, time and interaction in groups and time(P＜005). The postoperative astigmatism was decreased gradually in both groups, and the difference between time points was statistically significant(P＜005), there was no significant difference between groups and interaction in groups and time(P＞005). BUT and SⅠt in the two groups were decreased after operation. BUT and SⅠt in the observation group were higher than that in the control group, and there was significant difference between groups, time and interaction in groups and time(P＜005). The incidence of corneal edema, dry eye and total adverse reactions in the observation group were significantly lower than that in the control group(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Small incision nucleus combined with rhEGF eye drops for the treatment of nuclear cataract is effective, can significantly shorten the recovery time of postoperative visual acuity, promote the secretion of tears after surgery, and help reduce the incidence of postoperative complications. It is worth popularizing and applying in clinic.

Key words: cataract, small incision nucleus, epidermal growth factor

袁〓昱1，邵林海2*. 小切口劈核术联合rhEGF滴眼液治疗白内障患者的效果及对BUT、SⅠt的影响[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2019.06.015.

YUAN Yu1， SHAO Linhai2*. Effect of small incision nucleus fragmentation method combined with rhEGF eye drops on cataract patients and its effect on BUT and SⅠt#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2019.06.015.

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小切口劈核术联合rhEGF滴眼液治疗白内障患者的效果及对BUT、SⅠt的影响

Effect of small incision nucleus fragmentation method combined with rhEGF eye drops on cataract patients and its effect on BUT and SⅠt#br#

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