高渗盐水雾化联合化痰药物对重度毛细支气管炎临床效果及不良反应的影响

doi:10.3969/j.issn.1007-3205.2021.07.017

河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (7): 827-831.doi: 10.3969/j.issn.1007-3205.2021.07.017

高渗盐水雾化联合化痰药物对重度毛细支气管炎临床效果及不良反应的影响

河北省廊坊市人民医院儿二科，河北廊坊 065000

出版日期:2021-07-25 发布日期:2021-08-03
作者简介:刘颖辉（1984-），女，河北廊坊人，河北省廊坊市人民医院主治医师，医学学士，从事支气管相关疾病诊治研究。
基金资助:
廊坊市科技支撑计划项目（2016013177）

Effects of atomization inhalation of hypertonic saline combined with phlegm-reducing drugs on the clinical effect and adverse reactions of severe bronchiolitis

The Second Department of Pediatrics， People′s Hospital of Langfang City, Hebei Province， Langfang 065000， China

Online:2021-07-25 Published:2021-08-03

摘要/Abstract

摘要： 目的探讨高渗盐水雾化联合化痰药物对重度毛细支气管炎临床效果及不良反应的影响。
方法选择重度毛细支气管炎患儿80例，按照信封法分为单纯组和联合组，每组40例。单纯组采用化痰药物氨溴索静脉滴注治疗，联合组在单纯组治疗基础上联合高渗盐水雾化治疗。比较2组临床疗效、症状消除时间、炎性细胞、血气指标及不良反应发生情况。
结果联合组总有效率高于单纯组（P＜0.05）。联合组气促、哮鸣、咳嗽、喘憋消失时间均低于单纯组（P＜0.05）。治疗后，2组炎性细胞计数、中性粒细胞、嗜酸粒细胞、淋巴细胞低于治疗前，联合组炎性细胞计数、中性粒细胞、嗜酸粒细胞、淋巴细胞低于单纯组（P＜0.05）；2组动脉氧分压(arterial partial pressure of oxygen,Pa2)、血氧饱和度(blood oxygen saturation,SpO2)高于治疗前，PaCO2低于治疗前，联合组PaO2、SpO2高于单纯组，PaCO2低于单纯组（P＜0.05）。2组不良反应发生率差异无统计学意义(P＞0.05)。
结论高渗盐水雾化联合盐酸氨溴索治疗重症毛细支气管炎患儿效果更佳，能改善咳喘症状，减少中性粒细胞水平，提高氧气含量，安全性较高。

关键词: 支气管炎, 盐水, 高渗, 氨溴索

Abstract: Objective To investigate the effects of atomization inhalation of hyperosmotic saline combined with phlegm-reducing drugs on the clinical effects and adverse reactions of severe bronchiolitis.
Methods A total of 80 children with severe bronchiolitis were selected and divided into sinple group and combination group according to envelope method, with 40 cases in each group. The sinple group was treated with intravenous infusion of the expectorant ambroxol, while the combination group was treated with atomization inhalation of hypertonic saline on the basis of the sinple group. Clinical efficacy, time of symptom elimination, inflammatory cells, blood gas indexes and the incidence of adverse reactions were compared between two groups.
Results The total effective rate of combination group was higher than that of single group(P＜0.05). The disappearance time of shortness of breath, wheeze, cough and asthma in combination group were all lower than those in single group(P＜0.05). After treatment, the cell count, neutrophils, eosinophils and lymphocytes in two groups were lower than those before treatment, and the cell count, neutrophils, eosinophils and lymphocytes in the combination group were lower than those in the single group(P＜0.05). Arterial partial pressure of oxygen(PaO2) and blood oxygen saturation(SpO2) in both groups were higher than those before treatment, and PaCO2 was lower than that before treatment. PaO2 and SpO2 in combination group were higher, while PaCO2 in group 2 was lower, as compared with those in the single group(P＜0.05). There was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).
Conclusion Atomization inhalation of hypertonic saline combined with ambroxol hydrochloride is more effective in the treatment of children with severe bronchiolitis, which can improve cough and asthma symptoms, reduce the level of neutrophils, and improve oxygen content, with good safety.

Key words: bronchiolitis, saline solution, hypertonic, ambroxol

刘颖辉, 于冬辉, 李永红, 于丽英. 高渗盐水雾化联合化痰药物对重度毛细支气管炎临床效果及不良反应的影响[J]. 河北医科大学学报, 2021, 42(7): 827-831.

LIU Ying-hui, YU Dong-hui, LI Yong-hong, YU Li-ying. Effects of atomization inhalation of hypertonic saline combined with phlegm-reducing drugs on the clinical effect and adverse reactions of severe bronchiolitis[J]. Journal of Hebei Medical University, 2021, 42(7): 827-831.

[1]	司永华, 刘丽颖, 刘宝环, 高阳, 王荣. 硫酸镁雾化吸入辅助治疗对重症毛细支气管炎患儿气道阻力、肺功能及炎症因子的影响 [J]. 河北医科大学学报, 2023, 44(1): 86-90.
[2]	史军然，刘连凤，高虹，薛晋玲，杜杰静. 经鼻持续气道正压通气联合3%高渗盐水雾化吸入治疗重度毛细支气管炎的临床效果[J]. 河北医科大学学报, 2020, 41(3): 311-314.
[3]	白洪忠1，韩玮欣2，张雪萍3，李敬2，李雯4*. 鞘内注射异烟肼加地塞米松同时等量生理盐水置换治疗结核性脑膜炎的价值[J]. 河北医科大学学报, 2020, 41(1): 21-23,33.
[4]	贾系群，张中馥，郝改领，徐丽娟，李清华，马海民. 经鼻持续正压通气治疗中-重度毛细支气管炎的临床研究[J]. 河北医科大学学报, 2019, 40(9): 1005-1008.
[5]	刘连凤1，史军然1，薛红霞2，李三林1，高〓虹1. 高渗盐水联合肾上腺素雾化吸入治疗重症毛细支气管炎的疗效观察[J]. 河北医科大学学报, 2019, 40(4): 447-450,460.
[6]	杨芳芳1，尚朋娟2. 盐酸氨溴索联合常规治疗对新生儿肺炎的支气管黏膜纤毛结构及炎性因子的影响[J]. 河北医科大学学报, 2019, 40(2): 229-232.
[7]	任进民1，沈〓军2，孙〓莉1，马江曼1，崔晓红1. 注射用乳糖酸阿奇霉素与吸入用布地奈德混悬液的配伍稳定性考察[J]. 河北医科大学学报, 2017, 37(1): 66-71.
[8]	孙〓杰，张小坤. 不同途径给予氨溴索对ARDS患者炎症反应水平及疾病严重程度的影响[J]. 河北医科大学学报, 2016, 37(9): 1083-1087.
[9]	史军然 1,薛红霞 2,白瑞珍 1,张玉霞 1,周秀敏 1. 硫酸镁联合干扰素 α-1b 雾化吸入治疗重症毛细支气管炎的效果分析[J]. 河北医科大学学报, 2016, 37(1): 89-91.
[10]	项保利;汤建华;陈丽萍;李祯;胡亚丽;李艳云. 高渗盐雾化吸入治疗支气管扩张症的临床疗效观察[J]. , 2015, 36(8): 944-944.
[11]	亢泽坤;许萌;刘剑. 配置环境对盐酸氨溴索注射液与溶媒配伍后不溶性微粒的影响[J]. , 2015, 36(7): 807-807.
[12]	邱锐琴;顾艳红;乔木;苏颖. 孟鲁司特钠联合匹多莫德治疗毛细支气管炎的临床观察[J]. , 2014, 35(4): 444-444.
[13]	邱锐琴;乔木;顾艳红;苏颖. 孟鲁司特钠联合匹多莫德防治毛细支气管炎喘息反复发作的效果分析[J]. , 2014, 35(3): 280-280.
[14]	梁燕;李丽春;周玮;胡永红;胡国强;贾春生. 针刺治疗慢性支气管炎迁延期老年患者临床疗效及对免疫功能的影响[J]. , 2014, 35(3): 301-301.
[15]	邱锐琴;乔木;苏颖. 孟鲁司特钠对毛细支气管炎患儿血嗜酸性粒细胞趋化因子和干扰素γ的影响及其意义[J]. , 2014, 35(2): 156-156.

高渗盐水雾化联合化痰药物对重度毛细支气管炎临床效果及不良反应的影响

Effects of atomization inhalation of hypertonic saline combined with phlegm-reducing drugs on the clinical effect and adverse reactions of severe bronchiolitis

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价