CEACAM6、miR-146b、S100A6在甲状腺癌中的表达及意义分析

doi:10.3969/j.issn.1007-3205.2023.05.007

河北医科大学学报 ›› 2023, Vol. 44 ›› Issue (5): 531-535,552.doi: 10.3969/j.issn.1007-3205.2023.05.007

CEACAM6、miR-146b、S100A6在甲状腺癌中的表达及意义分析

广西壮族自治区钦州市第一人民医院甲状腺乳腺外科，广西钦州 535000

出版日期:2023-05-25 发布日期:2023-05-25
作者简介:赖盛联（1981-），男，广西玉林人，广西壮族自治区钦州市第一人民医院主治医师，医学学士，从事甲状腺肿瘤疾病诊治研究。
基金资助:
广西壮族自治区卫生健康委员会（Z20200562）

Expression and significance analysis of CEACAM6, miR-146b and S100A6 in thyroid cancer

Department of Thyroid and Breast Surgery, the First People′s Hospital of Qinzhou City, Guangxi Zhuang Autonomous Region， Qinzhou 535000， China

Online:2023-05-25 Published:2023-05-25

摘要/Abstract

摘要： 目的探讨甲状腺癌组织中癌胚抗原相关细胞黏附分子6（carcinoembryonic antigen related cell adhesion molecule 6，CEACAM6）、miR-146b、钙结合蛋白A6（calcium-binding protein A6，S100A6）表达与临床病理特征以及预后的关系。
方法选择我院收治的行甲状腺切除手术治疗的甲状腺癌患者165例，分别取癌组织和癌旁组织，采用实时荧光定量聚合酶链反应（real-time fluorescence quantitative polymerase chain reaction，RT-PCR）检测CEACAM6、miR-146b、S100A6表达。采用t检验甲状腺癌患者不同临床病理特征间CEACAM6、miR-146b、S100A6表达差异，Kaplan-Meier和Cox比例风险模型分析CEACAM6、miR-146b、S100A6表达与甲状腺癌患者预后的关系。
结果癌组织CEACAM6、miR-146b、S100A6表达高于癌旁组织（P＜0.05），肿瘤直径＞1 cm、低中度分化、T3~T4b期、N1a~N1b患者癌组织中CEACAM6、miR-146b、S100A6表达高于肿瘤直径≤1 cm、高度分化、T1~T2期、N0患者（P＜0.05）。CEACAM6高表达组、miR-146b高表达组、S100A6高表达组患者总生存率低于CEACAM6低表达组、miR-146b低表达组、S100A6低表达组（P＜0.05）。N1a~N1b、CEACAM6高表达、miR-146b高表达、S100A6高表达是甲状腺癌患者不良预后的危险因素（P＜0.05）。
结论甲状腺癌组织中CEACAM6、miR-146b、S100A6均呈高表达，且与甲状腺癌肿瘤临床病理特征以及预后不良有关。

关键词: 甲状腺肿瘤, 癌胚抗原, 钙结合蛋白A6

Abstract: Objective To investigate the relationship between the expression of carcinoembryonic antigen related cell adhesion molecule 6 (CEACAM6), miR-146b and calcium-binding protein A6 (S100A6) and clinicopathological features and prognosis in thyroid cancer.
Methods A total of 165 thyroid cancer patients who underwent thyroidectomy in our hospital were selected. The expressions of CEACAM6, miR-146b and S100A6 were detected by real-time fluorescence quantitative polymerase chain reaction (RT-PCR) in cancer tissues and adjacent tissues, respectively. A t-test was used to examine the expression differences of CEACAM6, miR-146b and S100A6 among different clinicopathological features of thyroid cancer patients. Kaplan-Meier and Cox proportional risk models were used to analyze the relationship between CEACAM6, miR-146b, S100A6 expression and prognosis of thyroid cancer patients.
Results The expressions of CEACAM6, miR-146b and S100A6 in cancer tissues were higher than those in adjacent tissues (P＜0.05). The expressions of CEACAM6, miR-146b and S100A6 in patients with tumor diameter ＞1 cm, low differentiation, T3- T4b and N1a-N1b were higher than those in patients with tumor diameter ≤1 cm, high differentiation, T1- T2 and N0 (P＜0.05). The overall survival rate of patients with high expression of CEACAM6, miR-146b and S100A6 were lower than those with low expression of CEACAM6, miR-146b and S100A6 (P＜0.05). High expression of N1a-N1b, CEACAM6, miR-146b and S100A6 were risk factors for poor prognosis of thyroid cancer patients (P＜0.05).
Conclusion CEACAM6, miR-146b and S100A6 are highly expressed in thyroid cancer tissues, which are related to the clinicopathological features and poor prognosis of thyroid cancer.

Key words: thyroid neoplasms, carcinoembryonic antigen, calcium-binding protein A6

赖盛联, 毛敏, 黄林. CEACAM6、miR-146b、S100A6在甲状腺癌中的表达及意义分析 [J]. 河北医科大学学报, 2023, 44(5): 531-535,552.

LAI Sheng-lian, MAO Min, HUANG Lin. Expression and significance analysis of CEACAM6, miR-146b and S100A6 in thyroid cancer [J]. Journal of Hebei Medical University, 2023, 44(5): 531-535,552.

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CEACAM6、miR-146b、S100A6在甲状腺癌中的表达及意义分析

Expression and significance analysis of CEACAM6, miR-146b and S100A6 in thyroid cancer

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