脑梗死继发癫痫患者脑干听觉诱发电位与脑血流量相关性及意义

doi:10.3969/j.issn.1007-3205.2023.07.010

摘要/Abstract

摘要： 目的探究脑梗死继发癫痫患者脑干听觉诱发电位（brainstem auditory e-voked potential，BAEP）与脑血流量（cerebral blood flow，CBF）相关性及意义。
方法选取脑梗死继发癫痫患者80例作为研究组，另选同期脑梗死未继发癫痫患者80例作为对照组。比较2组入院时一般资料、CBF、血清脂蛋白相关磷脂酶A2（lipoprotein-associated phospholipase A2，Lp-PLA2）、神经元烯醇化酶（neuronal-specific enolase，NSE）水平及BAEP评分，分析脑梗死继发癫痫患者BAEP评分与CBF、血清Lp-PLA2、NSE水平的相关性，并比较研究组不同癫痫特征（发作类型、放电类型、放电部位）患者BAEP评分，分析BAEP评分与脑梗死继发癫痫发作特征的相关性，通过受试者工作特征（receiver operating characteristic，ROC）曲线分析BAEP评分、CBF、Lp-PLA2、NSE预测脑梗死继发癫痫的价值。
结果研究组CBF低于对照组，血清Lp-PLA2、NSE水平及BAEP评分均高于对照组（P＜0.05）；研究组BAEP评分与CBF呈负相关，与血清Lp-PLA2、NSE水平呈正相关（P＜0.05）；研究组癫痫全面发作患者BAEP评分高于部分发作患者，多灶性放电患者BAEP评分高于局灶性放电患者（P＜0.05）；BAEP评分与脑梗死继发癫痫发作类型、放电类型呈正相关（P＜0.05）；BAEP评分、CBF、Lp-PLA2、NSE预测脑梗死继发癫痫的曲线下面积（area under the curve，AUC）均＞0.7，其中BAEP评分联合CBF、Lp-PLA2、NSE预测的AUC最大，为0.928（95%CI：0.876~0.963）。
结论脑梗死继发癫痫患者BAEP与CBF及血清Lp-PLA2、NSE水平密切相关，各指标联合在预测脑梗死继发癫痫方面具有较高预测效能。

关键词: 脑梗死, 癫痫, 脑干听觉诱发电位

Abstract: Objective To investigate the correlation and significance of brainstem auditory evoked potentials (BAEP) and cerebral blood flow (CBF) in patients with epilepsy secondary to cerebral infarction.
Methods A total of 80 patients with epilepsy secondary to cerebral infarction were selected as the research group, and another 80 patients without epilepsy secondary to cerebral infarction during the same period were selected as the control group. The general information, CBF, serum lipoprotein-associated phospholipase A2 (Lp-PLA 2), neuron-specific enolase (NSE) levels and BAEP scores at admission were compared between two groups. The BAEP scores of patients with different epileptic characteristics (seizure type, discharge type, discharge site) in the research group were compared, and the correlation between BAEP scores and CBF, serum Lp-PLA2, and NSE levels in patients with epilepsy secondary to cerebral infarction was analyzed, and BAEP scores in patients with different characteristics of epilepsy secondary to cerebral infarction were compared. The correlation between BAEP score and the characteristics of epilepsy secondary to cerebral infarction was analyzed, and the value of BAEP scores, CBF, Lp-PLA2, and NSE in predicting epilepsy secondary to cerebral infarction was analyzed by receiver operating characteristic (ROC) curve.
Results CBF was lower in the research group than in the control group, while serum Lp-PLA2 and NSE levels and BAEP scores were higher than those in the control group (P＜0.05). BAEP scores were negatively correlated with CBF and positively correlated with serum Lp-PLA2 and NSE levels in the research group (P＜0.05). BAEP scores were higher in patients with generalized seizures than in patients with partial seizures in the research group, and BAEP scores were higher in patients with multifocal discharge than in focal discharge patients (P＜0.05). BAEP scores were positively correlated with seizure type and discharge type in patients with epilepsy secondary to cerebral infarction (P＜0.05). The area under the curve (AUC) of BAEP scores, CBF, Lp-PLA2, and NSE in predicting epilepsy secondary to cerebral infarction was > 0.7, in which BAEP scores combined with CBF, Lp PLA2, and NSE in prediction had the largest AUC of 0.928 (95%CI: 0.876-0.963).
Conclusion BAEP in patients with epilepsy secondary to cerebral infarction is closely correlated with CBF and serum Lp-PLA2 and NSE levels, and the combination of the indicators has high predictive efficacy in predicting epilepsy secondary to cerebral infarction.

Key words: cerebral infarction, epilepsy, brainstem auditory evoked potentials

何琴, 杨小芳, 康瑜, 殷成坤. 脑梗死继发癫痫患者脑干听觉诱发电位与脑血流量相关性及意义 [J]. 河北医科大学学报, 2023, 44(7): 798-802,823.

HE Qin, YANG Xiao-fang, KANG Yu, YIN Cheng-kun. Correlation and significance of brainstem auditory evoked potentials and cerebral blood flow in patients with epilepsy secondary to cerebral infarction [J]. Journal of Hebei Medical University, 2023, 44(7): 798-802,823.

[1]	康丽娟, 李盼, 耿丽颖, 孟琦. 补体激活3a受体检测评估大剂量阿托伐他汀联合双联抗血小板治疗急性脑梗死的效果研究 [J]. 河北医科大学学报, 2023, 44(9): 1011-1016.
[2]	王琳, 徐正虎, 李可静, 范鸣玥, 王恒. DEVT与BT方案治疗急性大血管闭塞性脑梗死患者的效果及对预后的影响 [J]. 河北医科大学学报, 2023, 44(7): 786-791.
[3]	王荣辉, 王小卫, 张博刚. 替罗非班联合Solumbra取栓对急性颅内外大动脉闭塞脑梗死血管再通率及预后的影响 [J]. 河北医科大学学报, 2023, 44(7): 792-797.
[4]	张颖, 王佳荣, 张二娜, 赵智江, 陈晓艳, 刘芳芳. AIM2、Lp-PLA2、UCH-L1在急性脑梗死中的表达及预测价值研究 [J]. 河北医科大学学报, 2023, 44(4): 386-391.
[5]	俞登荣, 陈剑春, 吕焕焕, 姬瑞瑞. 两种药物联合治疗对病毒性脑炎相关癫痫患儿脑电图和血清IL-6、TNF-α水平的影响 [J]. 河北医科大学学报, 2023, 44(3): 315-318.
[6]	刘梓宸 , 李克娇, 畅莎, 宋雪, 李芳. RBP、miR-126、Sirt1在急性脑梗死中的表达及与颈动脉粥样硬化斑块稳定性的相关性 [J]. 河北医科大学学报, 2023, 44(2): 142-147.
[7]	焦俊萍, 鲍军强, 王志伟, 田书娟. 依达拉奉右莰醇对急性脑梗死静脉溶栓后的疗效观察[J]. 河北医科大学学报, 2022, 43(8): 884-889.
[8]	逯青丽, 刘仲仲, 刘佩, 王静, 蔺雪梅, 吴松笛. 老年首发脑梗死患者卒中相关性肺炎发生的危险因素及对早期结局的影响 [J]. 河北医科大学学报, 2022, 43(8): 890-894，914.
[9]	刘星, 董长征, 周笋, 康进生, 马万东. 迷走神经刺激术治疗难治性癫痫的临床效果及对认知功能的影响 [J]. 河北医科大学学报, 2022, 43(7): 792-795,826.
[10]	闫菁. 老年脑梗死后肩手综合征患者康复治疗效果相关影响因素的调查分析 [J]. 河北医科大学学报, 2022, 43(7): 839-843.
[11]	张红金, 顾金涛, 徐红梅. 老年H型高血压伴急性脑梗死患者外周血LP-PLA2、S100-β与病情严重程度及预后的关系分析 [J]. 河北医科大学学报, 2022, 43(12): 1378-1383.
[12]	李健, 潘为领, 赵晓阳, 宋冬梅. 氢质子磁共振波谱成像结合PET/MRI对癫痫的诊断价值分析 [J]. 河北医科大学学报, 2022, 43(12): 1474-1478.
[13]	陈灏, 胡菁菁. 联合检测hs-CRP、Hcy和凝血功能对急性脑梗死病情严重程度的评估价值分析 [J]. 河北医科大学学报, 2021, 42(6): 641-645.
[14]	逯青丽, 王静, 刘仲仲, 蔺雪梅, 王芳, 吴松笛. 西安地区伴吞咽障碍老年急性脑梗死患者的临床特征及对住院结局的影响 [J]. 河北医科大学学报, 2021, 42(6): 646-650.
[15]	唐甲凡, 翟万庆, 宋丽艳, 何晓燕, 周亦. 多种血清指标预测老年脑卒中后抑郁的临床价值[J]. 河北医科大学学报, 2021, 42(6): 651-655,660.

脑梗死继发癫痫患者脑干听觉诱发电位与脑血流量相关性及意义

Correlation and significance of brainstem auditory evoked potentials and cerebral blood flow in patients with epilepsy secondary to cerebral infarction

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价