河北医科大学学报 ›› 2024, Vol. 45 ›› Issue (2): 130-134.doi: 10.3969/j.issn.1007-3205.2024.02.002

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CagA阳性幽门螺杆菌感染与中年无症状人群CIMT相关性研究

  

  1. 1.首都医科大学附属北京康复医院急诊科，北京 100144；2.首都医科大学附属北京康复医院
    老年康复中心，北京 100144；3.首都医科大学附属北京康复医院放射科，北京 100144；
    4.首都医科大学附属北京康复医院劳模健康管理中心，北京 100144

  • 出版日期:2024-02-25 发布日期:2024-02-06
  • 作者简介:王明虎（1986-），男，山东潍坊人，首都医科大学附属北京康复医院主治医师，医学学士，从事心血管疾病诊治研究。
  • 基金资助:
    首都医科大学附属北京康复医院科技发展专项（2022-071）

Association between CagA-antibody-positive helicobacter pylori infection and carotid intima-media thickness in middle-aged asymptomatic population

  1. 1.Department of Emergency, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 
    100144, China; 2.Department of Geriatrics, Beijing Rehabilitation Hospital of Capital Medical 
    University, Beijing 100144, China; 3.Departments of Radiology, Beijing Rehabilitation 
    Hospital of Capital Medical University, Beijing 100144, China; 4.Center of Model 
    Worker Health Management, Beijing Rehabilitation Hospital of 
    Capital Medical University,  Beijing 100144, China

  • Online:2024-02-25 Published:2024-02-06

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摘要： 目的 探讨细胞毒素相关蛋白A( cytotoxin-associated protein A,CagA)阳性Hp感染与中年无症状人群颈动脉粥样硬化（carotid atherosclerosis,CAS）的相关性。
方法 选取在我院就诊的CAS患者578例作为CAS组，选取无CAS患者578例作为对照组，比较2组CagA阳性Hp感染比例，并作Logistic回归分析。比较CagA阳性Hp感染患者与CagA阴性患者颈动脉内-中膜厚度(carotid intima-media thick-ness,CIMT)。
结果 CAS组CagA阳性Hp感染患者比例高于对照组（P＜0.05）。CagA阳性Hp感染是CAS的独立危险因素(OR =1.813，95%CI：1.379~2.384，P＜0.05）。CagA阳性Hp感染患者CIMT大于CagA阴性患者（t=28.046，P＜0.05）。
结论 在中年无症状人群中，CagA阳性Hp感染是CAS的独立危险因素，CagA阳性Hp感染患者CIMT大于CagA阴性Hp感染患者。因此，CagA阳性Hp感染与CAS的发生、发展有关。


关键词: 幽门螺杆菌, 颈动脉粥样硬化, 细胞毒素相关蛋白A

Abstract: Objective To examine the association between CagA-antibody-positive helicobacter pylori (Hp) infection and carotid atherosclerosis (CAS) in middle-aged asymptomatic population. 
Methods A total of 578 CAS patients treated in our hospital were selected for this study, and 578 patients without CAS were selected as the control group. CagA-antibody-positive Hp infection was compared between two groups, and logistic regression analysis was conducted. Carotid intima-media thickness(CIMT) was compared between patients with CagA-antibody-positive Hp infection and those with CagA-antibody-negative Hp infection. 
Results The CAS group had significantly higher frequency of CagA-antibody-positive Hp infection than the controls (P＜0.05). CagA-antibody-positive Hp infection was an independent risk factors for CAS (OR=1.813, 95% CI: 1.379-2.384, P＜0.05). CIMT was significantly greater in patients with CagA-antibody-positive Hp infection than in those with CagA-antibody-negative Hp infection (t=28.046, P＜0.05). 
Conclusion In middle-aged asymptomatic population， CagA-antibody-negative Hp infection is an independent risk factor for CAS. The levels of CIMT in patients with CagA-antibody-positive Hp infection are significantly higher than those of patients with CagA-antibody-negative Hp infection. Thus, CagA-antibody-positive Hp infection has been implicated in the development and progression of CAS. 


Key words: helicobacter pylori, carotid atherosclerosis, cytotoxin-associated protein A

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