河北医科大学学报 ›› 2025, Vol. 46 ›› Issue (5): 611-616.doi: 10.3969/j.issn.1007-3205.2025.05.019

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IL-6基因多态性与结核病易感性的荟萃分析

  

  1. 安徽医科大学第一附属医院感染病科，感染性疾病安徽省重点实验室，安徽 合肥 230022

  • 出版日期:2025-05-25 发布日期:2025-05-23
  • 作者简介:张亚龙（1989-），男，安徽蚌埠人，安徽医科大学第一附属医院主管技师，医学硕士，从事基因多态性与疾病相关性研究。

  • 基金资助:
    国家自然科学基金（82370608）；安徽省教育厅高校科学研究项目（KJ2021A0285）

Meta-analysis of interleukin-6 gene polymorphism and susceptibility to tuberculosis

  1. Department of Infectious Diseases, the First Hospital of Anhui Medical University/Anhui Province Key Laboratory of Infectious Diseases, Hefei 230022, China
  • Online:2025-05-25 Published:2025-05-23

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摘要： 目的 探讨白细胞介素6（interleukin-6,IL-6）基因多态性与结核病易感性的关系。
方法 检索中国知网、万方、Pubmed、Web of Science数据库中有关IL-6-174G/C（rs1800795)和-572G/C(rs1800796)与结核病易感性的研究，文献检索时间范围均限至2024年3月。由2名研究者独立采用统一的纳入标准筛选出数据，采用STATA12.0进行Meta分析，以合并优势比(odds ratio,OR)及其95%置信区间（confidence interval,CI）评估关联强度。
结果 最后纳入15个病例-对照研究，包括结核组2 416例和健康组3 060例。Meta分析结果表明IL-6-174 G/C位点多态性与结核病发病均存在显著相关性［C vs. G:OR=0.66，95%CI：0.59~0.75，P＜0.001；CC+CG vs. GG:OR=0.67，95%CI：0.57~0.78，P＜0.001;CC vs. GC+GG:OR=0.48，95%CI：0.29~0.82，P=0.007；CC vs. GG:OR=0.38,95%CI：0.27~0.52，P＜0.001;CG vs. GG:OR=0.75,95%CI：0.63~0.88，P＜0.001］。在等位基因模型（C vs. G）下，IL-6-572G/C位点多态性与结核病发病存在显著相关性［C vs. G:OR=0.87，95%CI：0.76~0.99，P=0.038］。而在其余4种模型下，与结核病发病均不存在相关性［CC+CG vs. GG:OR=0.72，95%CI：0.51~1.01，P=0.054;CC vs. GC+GG:OR=1.28，95%CI：0.61~2.72，P=0.512；CC vs. GG:OR=0.95,95%CI：0.54~1.67，P=0.867;CG vs. GG:OR=0.68,95%CI：0.46~1.02，P=0.060］ 。
结论 IL-6基因174G＞C位点和572G＞C位点多态性可能会降低结核病发病的风险。


关键词: 结核, 白细胞介素6, 荟萃分析

Abstract: Objective To investigate the relationship between genetic polymorphism of interleukin-6 (IL-6) and susceptibility to tuberculosis (TB). 
Methods CNKI, WanFang, Pubmed and Web of Science databases were searched to collect studies on relationship between IL-6-174G/C (rs1800795), -572G/C(rs1800796) and susceptibility to TB until March 2024. Data were screened independently by two researchers using uniform inclusion criteria, and Meta-analysis was performed using STATA12.0. Combined odds ratio (OR) and its 95% confidence interval (95%CI) were used to evaluate the correlation strength. 
Results Finally, 15 case-control studies were included, including 2 416 people in the TB group and 3 060 people in the healthy group. The results of Meta-analysis showed that the polymorphism of IL-6-174G/C was associated with the risk of TB infection ［C vs. G: OR=0.66，95%CI: 0.59-0.75, P＜0.001; CC+CG vs. GG: OR=0.67, 95%CI: 0.57-0.78, P＜0.001; CC vs. GC+GG:OR=0.48, 95%CI: 0.29-0.82, P=0.007; CC vs. GG: OR=0.38, 95%CI: 0.27-0.52, P＜0.001; CG vs. GG: OR=0.75, 95%CI: 0.63-0.88, P＜0.001］. IL-6-572G/C polymorphism was significantly associated with TB infection in the allele model (C vs. G)［ C vs. G:OR=0.87, 95%CI: 0.76-0.99, P=0.038］; however, it was not associated with the incidence of TB in the other four models ［CC+CG vs. GG: OR=0.72, 95%CI: 0.51-1.01，P=0.054; CC vs. GC+GG: OR=1.28, 95%CI: 0.61-2.72, P=0.512; CC vs. GG: OR=0.95, 95%CI: 0.54-1.67，P=0.867; CG vs. GG: OR=0.68, 95%CI: 0.46-1.02, P=0.060］. 
Conclusion The 174G＞C and 572G＞C polymorphisms of the IL-6 gene may decrease the risk of TB development. 


Key words: tuberculosis, interleukin-6, Meta-analysis

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