FEER、NEU%、IL-6、RBC-C3bR在脑梗死继发Ⅲ、Ⅳ度褥疮感染患者中表达及与预测创面愈合的价值研究

doi:10.3969/j.issn.1007-3205.2021.10.004

摘要/Abstract

摘要： 目的探讨免疫黏附促进因子（forming enhancement rosetterate，FEER）、中性粒细胞百分比（neutrophil%，NEU%）、白细胞介素6（interleukin-6，IL-6）、红细胞C3b受体花环率（erythrocyte C3b receptor wreath rate，RBC-C3bR）在脑梗死继发Ⅲ、Ⅳ度褥疮感染患者中表达及对创面愈合的预测价值。
方法选取北京市房山区良乡医院收治的43例脑梗死继发Ⅲ度褥疮感染者（Ⅲ度组）、43例脑梗死继发Ⅳ度褥疮感染者（Ⅳ度组）及43例正常人群（对照组），比较各组一般资料、FEER、NEU%、IL-6、RBC-C3bR水平，采用Spearman分析FEER、NEU%、IL-6、RBC-C3bR与褥疮分度的关系，比较创面愈合与未愈合者治疗前、治疗10 d和20 d FEER、NEU%、IL-6、RBC-C3bR水平及褥疮愈合计分量表（pressure ulcer scale for healing，PUSH）评分，采用Pearson分析FEER、NEU%、IL-6、RBC-C3bR与PUSH评分的相关性，采用受试者工作特征曲线（receiver operating characteristic，，ROC）及ROC下面积（area under the curve，AUC）分析各指标预测创面愈合的价值。
结果 FEER、RBC-C3bR：Ⅳ度组＜Ⅲ度组＜对照组，NEU%、IL-6：Ⅳ度组＞Ⅲ度组＞对照组，组间比较差异有统计学意义（P＜0.05）；FEER、RBC-C3bR与褥疮分度呈负相关，NEU%、IL-6与褥疮分度呈正相关（P＜0.05）；治疗10 d后创面愈合者FEER、RBC-C3bR呈升高趋势，NEU%、IL-6呈降低趋势，且治疗20 d各指标与治疗10 d比较，差异有统计学（P＜0.05）；创面未愈合者治疗10 d FEER、RBC-C3bR高于治疗前，NEU%、IL-6低于治疗前（P＜0.05），但治疗20 d各指标与治疗10 d各指标比较，差异无统计学意义（P＞0.05）；创面愈合者治疗10 d、20 d FEER、RBC-C3bR高于未愈合者，NEU%、IL-6低于未愈合者（P＜0.05）；治疗10 d与20 d FEER、RBC-C3bR与PUSH评分呈负相关，NEU%、IL-6与PUSH评分呈正相关（P＜0.05），治疗10 d的相关性强于治疗20 d；预测创面愈合的AUC：IL-6（0.823）＞NEU%（0.819）＞FEER（0.714）＞RBC-C3bR（0.709），各指标联合为0.896（P＜0.05）。
结论脑梗死继发Ⅲ、Ⅳ度褥疮感染患者治疗前FEER、RBC-C3bR表达显著降低，NEU%、IL-6表达显著升高，治疗后FEER、RBC-C3bR升高及NEU%、IL-6降低可预示创面趋于愈合，检测治疗后10 d各指标水平有望成为预测创面愈合的生物标志物。

关键词: 脑梗死, 压力性溃疡, 白细胞介素6

Abstract: Objective To investigate the expression of forming enhancement rosette rate(FEER), neutrophil %(NEU%), interleukin-6(IL-6), and erythrocyte C3b receptor wreath rate(RBC-C3bR) in patients with Ⅲ and Ⅳ degree bedsore infection secondary to cerebral infarction and their predictive value in wound healing.
Methods A total of 43 patients with Ⅲ degree bedsore infection secondary to cerebral infarction(Ⅲ degree group), 43 patients with Ⅳ degree bedsore infection secondary to cerebral infarction(Ⅳ degree group) and 43 healthy people(control group) were selected from Liangxiang Hospital of Fangshan District in Beijing. The general data, FEER, NEU%, IL-6, and RBC-C3bR levels of each group were compared, and Spearman correlation analysis was used to analyze the relationship between FEER, NEU%, IL-6, RBC-C3bR and the degree of bedsore. The FEER, NEU%, IL-6, RBC-C3bR levels and the Pressure Ulcer Scale for Healing(PUSH) scores of patients with healed and unhealed wound before treatment, at 10 d and 20 d after treatment were compared. Pearson analysis was used to analyze the correlation between FEER, NEU%, IL-6, RBC-C3bR and PUSH score, and receiver operating characteristic curve(ROC) and area under ROC(AUC) were used to analyze the value of each index in predicting wound healing.
Results FEER and RBC-C3bR were the lowest in Ⅳ degree group, followed by Ⅲ degree group and control group, while NEU% and IL-6 were the highest in Ⅳ degree group, followed by Ⅲ degree group and control group, suggesting significant difference between groups(P＜0.05). FEER and RBC-C3bR were negatively correlated with the degree of bedsore, and NEU% and IL-6 were positively correlated with the degree of bedsore(P＜0.05). At 10 d after treatment, the FEER and RBC-C3bR of the patients with healed wound showed an increasing trend, and the NEU% and IL-6 showed a decreasing trend; there were statistically significant differences between the indicators at 20 d after treatment and those at 10 d after treatment(P＜0.05). The FEER and RBC-C3bR of patients with unhealed wounds at 10 d after treatment were higher than those before treatment, and NEU% and IL-6 were lower than those before treatment(P＜0.05). However, there was no statistically significant difference between the indexes at 20 d after treatment and those at 10 d after treatment(P＞0.05). The FEER and RBC-C3bR of patients with healed wound were higher than those of patients with unhealed wound at 10 d and 20 d after treatment, and the NEU% and IL-6 were lower than those of the unhealed(P＜0.05). FEER and RBC-C3bR at 10 d and 20 d after treatment were negatively correlated with PUSH score, while NEU% and IL-6 were positively correlated with PUSH score(P＜0.05), and the correlation at 10 d after treatment was stronger than that at 20 d after treatment. The AUC for predicting wound healing was the largest in IL-6(0.823), followed by NEU%(0.819), FEER(0.714) and RBC-C3bR(0.709), and the AUC of the combination of indicators was 0.896(P＜0.05).
Conclusion The expressions of FEER and RBC-C3bR in patients with Ⅲ and Ⅳ degree bedsore infection secondary to cerebral infarction decreased significantly, and the expressions of NEU% and IL-6 increased significantly before treatment. After treatment, the increase of FEER, RBC-C3bR and the decrease of NEU% and IL-6 can indicate that the wound tends to heal. The detection of the level of each index at 10 d after treatment is expected to become a biomarker for predicting wound healing.

Key words: brain infarction, pressure ulcer, interleukin-6

鲍利改, 董谦. FEER、NEU%、IL-6、RBC-C3bR在脑梗死继发Ⅲ、Ⅳ度褥疮感染患者中表达及与预测创面愈合的价值研究[J]. 河北医科大学学报, 2021, 42(10): 1133-1138.

BAO Li-gai, DONG Qian. Expression of FEER, NEU%, IL-6, RBC-C3bR in patients with Ⅲ and Ⅳ degree bedsore infection secondary to cerebral infarction and their value in predicting wound healing[J]. Journal of Hebei Medical University, 2021, 42(10): 1133-1138.

[1]	康丽娟, 李盼, 耿丽颖, 孟琦. 补体激活3a受体检测评估大剂量阿托伐他汀联合双联抗血小板治疗急性脑梗死的效果研究 [J]. 河北医科大学学报, 2023, 44(9): 1011-1016.
[2]	王琳, 徐正虎, 李可静, 范鸣玥, 王恒. DEVT与BT方案治疗急性大血管闭塞性脑梗死患者的效果及对预后的影响 [J]. 河北医科大学学报, 2023, 44(7): 786-791.
[3]	王荣辉, 王小卫, 张博刚. 替罗非班联合Solumbra取栓对急性颅内外大动脉闭塞脑梗死血管再通率及预后的影响 [J]. 河北医科大学学报, 2023, 44(7): 792-797.
[4]	何琴, 杨小芳, 康瑜, 殷成坤. 脑梗死继发癫痫患者脑干听觉诱发电位与脑血流量相关性及意义 [J]. 河北医科大学学报, 2023, 44(7): 798-802,823.
[5]	张颖, 王佳荣, 张二娜, 赵智江, 陈晓艳, 刘芳芳. AIM2、Lp-PLA2、UCH-L1在急性脑梗死中的表达及预测价值研究 [J]. 河北医科大学学报, 2023, 44(4): 386-391.
[6]	刘梓宸 , 李克娇, 畅莎, 宋雪, 李芳. RBP、miR-126、Sirt1在急性脑梗死中的表达及与颈动脉粥样硬化斑块稳定性的相关性 [J]. 河北医科大学学报, 2023, 44(2): 142-147.
[7]	焦俊萍, 鲍军强, 王志伟, 田书娟. 依达拉奉右莰醇对急性脑梗死静脉溶栓后的疗效观察[J]. 河北医科大学学报, 2022, 43(8): 884-889.
[8]	逯青丽, 刘仲仲, 刘佩, 王静, 蔺雪梅, 吴松笛. 老年首发脑梗死患者卒中相关性肺炎发生的危险因素及对早期结局的影响 [J]. 河北医科大学学报, 2022, 43(8): 890-894，914.
[9]	闫菁. 老年脑梗死后肩手综合征患者康复治疗效果相关影响因素的调查分析 [J]. 河北医科大学学报, 2022, 43(7): 839-843.
[10]	张红金, 顾金涛, 徐红梅. 老年H型高血压伴急性脑梗死患者外周血LP-PLA2、S100-β与病情严重程度及预后的关系分析 [J]. 河北医科大学学报, 2022, 43(12): 1378-1383.
[11]	陈灏, 胡菁菁. 联合检测hs-CRP、Hcy和凝血功能对急性脑梗死病情严重程度的评估价值分析 [J]. 河北医科大学学报, 2021, 42(6): 641-645.
[12]	逯青丽, 王静, 刘仲仲, 蔺雪梅, 王芳, 吴松笛. 西安地区伴吞咽障碍老年急性脑梗死患者的临床特征及对住院结局的影响 [J]. 河北医科大学学报, 2021, 42(6): 646-650.
[13]	唐甲凡, 翟万庆, 宋丽艳, 何晓燕, 周亦. 多种血清指标预测老年脑卒中后抑郁的临床价值[J]. 河北医科大学学报, 2021, 42(6): 651-655,660.
[14]	张鑫宇, 赵鑫, 张重阳, 王耀辉, 刘宇鹏. 局部亚低温联合rt-PA静脉溶栓治疗对急性大面积脑梗死患者氧化应激、神经功能损伤及预后的影响[J]. 河北医科大学学报, 2021, 42(2): 158-162.
[15]	赵永强, 王钒, 王成健, 李正平, 张宇晗, 张玉. MRI对成人可逆性胼胝体压部病变综合征和脑梗死的鉴别诊断及预后评估[J]. 河北医科大学学报, 2021, 42(2): 209-213.

FEER、NEU%、IL-6、RBC-C3bR在脑梗死继发Ⅲ、Ⅳ度褥疮感染患者中表达及与预测创面愈合的价值研究

Expression of FEER, NEU%, IL-6, RBC-C3bR in patients with Ⅲ and Ⅳ degree bedsore infection secondary to cerebral infarction and their value in predicting wound healing

HTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价