Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the clinical application value of detecting serum microRNA206， 155 in predicting hyperthyroidism relapse after drug withdrawal.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expression levels of serum microRNA206，155 in 142 patients with hyperthyroidism were detected by  technology(45 cases in the nontreatment group, 41 cases in the relapse group and 56 cases in the nonrelapse group) in detecting serum T3, T4 and TSH levels by the electrochemical luminescence technology. The inner diameter(diameter, D) and the maximum systolic blood flow velocity(peak systolic velocity, Vmax) of the superior thyroid artery(superior thyroid, STA) were examined by color Doppler ultrasonography.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓In the relapse group and the nontreatment group, the levels of T4,T3, STAD and Vmax were higher than those in the nonrelapse group, respectively, but TSH were lower（P＜005). The levels of T4, T3, TSH, STAD and Vmax between the relapse group and the nontreatment group were compared, but without statistically significant difference（P＞005). The expression of miRNA206 was negatively correlated with the expression of miRNA155(r=-0.692, P＜001). MiRNA206 expression was negatively correlated with T4, T3, STAD and Vmax(r=-0.562, -0.593, -0.537, -0.519, P＜001) and positively correlated with TSH(r=0.622, P＜001). The expression of miRNA155 was positively correlated with serum T4, T3, STAD and Vmax(r=0.530, 0.562, 0.553, 0.503, P＜001), and negatively correlated with TSH(r=-0.689, P＜001). The sensitivity and specificity of miRNA206 and miRNA155 in the diagnosis of hyperthyroidism at the best critical value were 93.2% and 90.7%, 91.6% and 97.2%, respectively.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The detection of serum microRNA206, 155 can be used in prediction of hyperthyroidism relapse after discontinuation of medicine treating, and may be an useful warning markers and intervention targets for hyperthyroidism treating.

Key words: hyperthyroidism, recurrence, microRNAs