Abstract: Objective  To investigate and analyze the micro ribonucleic acid（miRNA） expression differences in patients with human papillomavirus 18（HPV 18）and different pathological types of cervical cancer. 
Methods  Thirty patients with HPV18 positive cervical adenocarcinoma were chosen as the group A，30 patients with HPV18 positive cervical squamous carcinoma at the same time were chosen as the group B， 15 persons with normal cervix at the same time were chosen as the group C. Then the tissue differentially expressed miRNA of group A and group B were tested，and the expression situation of differentially expressed miRNA and target gene of three groups were compared，the expression situation of group A with different ages，stages，differentiation degree and transfer situation were compared too. 
Results  The differentially expressed miRNA of group A and group B were miR-34 and miR-19. The miR-19 and survivin of group A were significantly higher than those of group B. The miR-34 and phosphatase and tensin homolog deleted on chromosome ten（PTEN）were significantly lower than those of group B. The expression of group A and group B were significantly different from group C， there were statistically significant differences（P＜0.05）. The expression situation of group A with different ages were compared， there were no statistically significant differences（P＞0.05）. The expression situation of group A with different stages， differentiation degree and transfer situation were compared， there were statistically significant differences（P＜0.05）.
Conclusion  The expression differences of miR-19， miR-34， survivin and PTEN in patients with HPV 18 and different pathological types of cervical cancer are significant， and the expression differences of patients with different stages， differentiation degree and transfer situation are obvious. 

Key words: uterine cervical neoplasms, human papillomavirus 18, microRNAs