Abstract: ［Abstract］ Objective To investigate the effects of dipyridamole and tacrolimus on high coagulation state and serum soluble intercellular adhesion molecule-1(sICAM-1) in children with steroid-resistant Henoch-Schonlein purpura.
Methods Ninety children with steroid-resistant Henoch-Schonlein purpura were randomly divided into control group and observation group, 52 cases in each group. The control group received heparin combined with dipyridamole on the basis of routine treatment, and the observation group were given tacrolimus on the basis of control group. The clinical effect and the time of clinical symptom disappearance between the two groups were compared. And the changes of coagulation indexes and serum level of sICAM-1 before and after treatment were detected.
Results The total effective rate of observation group was significantly higher than that of control group(P＜0.05). The clinical symptoms of joint swelling, rash and abdominal pain in the observation group were significantly shorter than those in the control group(P＜0.05). After treatment, the D-Dimer level of the observation group was significantly lower than that in the control group, while the prothrombin time, thrombin time and activated partial thromboplastin time levels were significantly higher than those in the control group(P＜0.05). The serum level of sICAM-1 in the observation group was significantly lower than that in the control group(P＜0.05).
Conclusion Dipyridamole combined with tacrolimus in the treatment of steroid-resistant Henoch-Schonlein purpura children is significantly effective, it can significantly improve the blood coagulation index, inhibit the immune response, reduce serum sICAM-1, promote the remission of children′s symptoms.

Key words: purpura, schoenlein-henoch, dipyridamole, tacrolimus