Abstract: ［Abstract］Objective〖HTSS〗To investigate the clinical characteristics and prognostic significance of transcription factor TFCP2 in patients with esophageal squamous cell carcinoma(ESCC).
 〖WTHZ〗Methods〖HTSS〗The expression of transcription factor TFCP2 in 80 ESCC specimens and corresponding normal tissues were detected by immunohistochemistry and its association with clinical characteristics and prognosis were analyzed.
 〖WTHZ〗Results〖HTSS〗The positive rates of TFCP2 in ESCC was higher than that in normal tissues（P＜0.01）.TFCP2 was correlated with clinical stage, lymph node metastatis and distant metastasis in patients with ESCC（P＜0.05 or P＜0.01）. TFCP2 was not correlated with age, gender, family history of UGIC, histological grade and tumor size(P＞0.05). Kaplan-Meier analysis showed that ESCC patients with high TFCP2 expression had worse prognosis than those with low TFCP2 expression. Multivariate Cox proportional hazard regression model showed that the expression of TFCP2, lymph node metastasis and distant metastasis were independently related to the survival rate of ESCC patients.
 〖WTHZ〗Conclusion〖HTSS〗Transcription factor TFCP2 is associated with antigen in ESCC tisuses and can be a biomarker of poor prognosis in patients with ESCC.

Key words: esophageal neoplasms, transcriptional factor cp2, prognosis