Abstract: Objective  To investigate the serum levels of Hepcidin and their clinical significance in children with acute lymphoblastic leukemia(ALL). 
Methods  A total of 30 children with ALL were selected as the study subjects. They were followed up up to February 2020. Serum Hepcidinlevels and erythropoietin(EPO) were detected by enzyme-linked immunosorbent assay(ELISA).The blood analyzer was used to detect the hemoglobin(HGB) level of the subjects, and the Ferritin, Transferrin and C-reactive protein(CRP) levels of the subjects were detected by the special protein immunoanalyzer.The relationship between the Hepcidin level and the prognosis of ALL children was analyzed, as well as the correlation of Hepcidin with EPO, HGB, Ferritin and Transferrin. 
Results  ①All 30 patients with ALL were divided into two groups according to the expression level of Hepcidin. The expression level of Hepcidin was(114.4±48.63) μg/L in the high Hepcidin level group and(21.98±15.94) μg/L in the low Hepcidin level group, with significant difference(P＜0.001). ②The total 5-year EFS of 30 ALL patients was 77.586%. There was no statistically significant difference in survival curves between the high and low Hepcidin level groups(P＞0.05). ③There was a positive correlation between Hepcidin and Ferritin concentration(r=0.466， P=0.010). There was a negative correlation betweenHepcidin level and HGB content(r=-0.407， P=0.026). 
Conclusion  ①Serum Hepcidin level in ALL children is not an independent factor affecting prognosis. ②The expression of Hepcidin in children with ALL is negatively correlated with the hemoglobin content, and positively correlated with the Ferritin concentration. Abnormal iron metabolism may be the cause of anemia in children with ALL.

Key words: leukemia, B-cell, hepcidin, prognosis