Abstract: Objective To investigate the effects of levetiracetam and oxazepine on EEG background activity, serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in children with viral meningitis-related seizures. 
Methods A total of 118 patients with seizure due to viral encephalitis were selected and divided into the control group and the research group according to random number table method. The research group was given oxazepine, and the control group was given levetiracetam. Both groups were treated for 6 consecutive months. The seizure control rate of the two groups at 1 month, 3 months and 6 months after treatment were recorded, and the EEG discharge function before treatment, at 3 months and 6 months after treatment were evaluated and analyzes. The changes in TNF-α and IL-6 levels were recorded. 
Results The complete control rate and total effective rate in the research group were significantly higher than those in the control group at 1 month, 3 months and 6 months after treatment (P＜0.05). After treatment, α and θ power in both groups was significantly higher than that before treatment (P＜0.05). At 3 months and 6 months after treatment,α and θ power in the research group was significantly higher than that of the control group (P＜0.05). The levels of TNF-α and IL-6 in both groups were lower than those before treatment, and lower in the research group than in the control group (P＜0.05). 
Conclusion Oxazepine can effectively reduce the level of serum inflammatory factors in children with viral meningitis-related seizures, and its effect on the background activity of EEG is smaller than that of levetiracetam, with good safety . Therefore, it is worthy of popularization and clinical application. 

Key words: encephalitis, viral, epilepsy, levoethoxetam, ocazepine