Abstract: Objective To investigate the expression and clinical significance of serum serpin family A member 1 (SERPINA1), connective tissue growth factor (CTGF), and total antioxidant capacity (T-AOC) in patients with uterine leiomyoma. 
Methods A total of 82 patients with uterine leiomyoma were included in the uterine leiomyoma group, and 68 healthy people undergoing physical examination during the same period were selected as the healthy control group. The expression of serum SERPINA1, CTGF, T-AOC in the two groups was compared. The expression of SERPINA1, CTGF, T-AOC in the serum of patients with different clinical characteristics of uterine leiomyoma was compared. The correlation between SERPINA1, CTGF, T-AOC and uterine leiomyoma was analyzed, and the efficacy of SERPINA1, CTGF, and T-AOC in the detection of uterine leiomyoma was analyzed. 
Results The levels of SERPINA1 and CTGF in serum of uterine leiomyoma group were higher than those of healthy control group, while the levels of T-AOC were lower than those of healthy control group (P＜0.05). Serum SERPINA1 and CTGF levels in patients with uterine leiomyoma and irregular vaginal bleeding were higher than those without irregular vaginal bleeding, and T-AOC levels were lower than those without irregular vaginal bleeding (P＜0.05). Spearman correlation coefficient analysis showed that serum SERPINA1 and CTGF were significantly positively correlated with uterine leiomyoma, while T-AOC was significantly negatively correlated with uterine leiomyoma (P＜0.05). The diagnostic efficacy of combined detection of serum SERPINA1, CTGF and T-AOC was significantly better than that of single detection (P＜0.001). 
Conclusion Serum SERPINA1, CTGF and T-AOC are abnormally expressed in patients with uterine leiomyoma, and the combined detection of these three indicators is more effective in the diagnosis of uterine leiomyoma.

Key words: leiomyoma, serpin family member 1, connective tissue growth factor, total antioxidant capacity