Abstract: Objective To explore the reproducibility, reliability, and consistency of lumbar bone mineral density (BMD) measured by FTHK software and Mindways (MW) quantitative CT Pro software and its application in clinical practice. 
 Methods A total of 708 patients who needed to undergo conventional abdominal CT scan were selected, and scan data were transmitted to FTHK and MW bone densitometry software for measurement. The paired-sample t-test, Pearson correlation analysis, intraclass correlation coefficient (ICC), Bland-Altman analysis, and Cronbach′s α coefficient were used to analyze the measurement results of the two groups. 
 Results ICC of both the FTHK and MW software for measurement of BMD was 0.976 and 0.936, respectively. The BMD value ［(126.29±50.16) mg/cm3］ measured by FTHK was higher than that ［(112.85±46.02) mg/cm3］ measured by MW, and the difference was 10.6% （P＜0.05). The detection rate of OP by FTHK software (19.63%) was lower than that measured by MW software (25.42%) (P＜0.05). There was a significant positive correlation in BMD values between the FTHK and MW analyses (r=0.955， P＜0.01). According to the results of Bland-Altman analysis, the difference of 95% was within the ± 1. 96 standard deviation of the average difference value. The FTHK had a Cronbach′s α coefficient =0.963, and the MW had a Cronbach′s α coefficient =0.988. 
 Conclusion The reliability and consistency of BMD measured by the FTHK and MW are good, and they can be used for the diagnosis of opportunistic osteoporosis.

Key words: osteoporosis, bone mineral density, tomography, X-ray computed